ENSDARG00000004378


Danio rerio

Features
Gene ID: ENSDARG00000004378
  
Biological name :yrk
  
Synonyms : Yes-related kinase / yrk
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 43359075
Gene end: 43432415
  
Corresponding Affymetrix probe sets: Dr.12726.1.S1_at (Zebrafish Array)   NM_212781_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000125669
Ensembl peptide - ENSDARP00000146571
Ensembl peptide - ENSDARP00000145924
Ensembl peptide - ENSDARP00000121344
Ensembl peptide - ENSDARP00000122444
Ensembl peptide - ENSDARP00000123169
Ensembl peptide - ENSDARP00000124796
NCBI entrez gene - 337571     See in Manteia.
RefSeq - NM_212781
RefSeq Peptide - NP_997946
swissprot - F8W2A7
swissprot - I3IS06
swissprot - Q8AWF1
swissprot - A5WWJ8
swissprot - A5WWJ6
ZFIN ID - ZDB-GENE-030131-9517
Ensembl - ENSDARG00000004378
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGRENSGALG00000032199Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*ENSDARG0000001137080
fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*ENSDARG0000002531979
yes1 / clul1 / A1A5H8 / clusterin-like 1 (retinal) / P07947* / Q04736* / YES proto-oncogene 1, Src family tyrosine kinase*ENSDARG0000000594173
src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...ENSDARG0000000810768
hck / HCK proto-oncogene, Src family tyrosine kinase / P08103* / P08631* / Tyrosine-protein kinase HCK *ENSDARG0000005864756
blk / BLK proto-oncogene, Src family tyrosine kinase / P16277* / P51451* / Tyrosine-protein kinase Blk *ENSDARG0000000778353
lyn / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*ENSDARG0000006791653
lck / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *ENSDARG0000010252550
frk / fyn-related Src family tyrosine kinase / P42685* / Q922K9* / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA.*ENSDARG0000002780748
ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*ENSDARG0000005995637
ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*ENSDARG0000001794736
SRMS / zgc:194282 / Q9H3Y6* / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites*ENSDARG0000007778335


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035693  Tyrosine-protein kinase Fgr, SH2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007229 integrin-mediated signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0048246 macrophage chemotaxis IMP
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009141 macrophage macrophage response to wounding process quality , abnormal
Show

 ZFA:0009327 neutrophil neutrophil response to wounding process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr