ENSDARG00000020164


Danio rerio

Features
Gene ID: ENSDARG00000020164
  
Biological name :efnb2a
  
Synonyms : efnb2a / ephrin-B2a / O73874
  
Possible biological names infered from orthology : EFNB2 / ephrin B2 / P52799 / P52800
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 26103814
Gene end: 26127305
  
Corresponding Affymetrix probe sets: Dr.5742.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000010432
NCBI entrez gene - 30219     See in Manteia.
swissprot - B0CLY3
swissprot - O73874
ZFIN ID - ZDB-GENE-990415-67
Ensembl - ENSDARG00000020164
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EFNB2ENSGALG00000029175Gallus gallus
 EFNB2ENSG00000125266Homo sapiens
 Efnb2ENSMUSG00000001300Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
efnb2b / ephrin-B2b / EFNB2* / P52800* / P52799* / ephrin B2*ENSDARG0000007405061
efnb1 / ephrin-B1 / P52795* / P98172*ENSDARG0000000772352
efnb3b / ephrin-B3b / EFNB3* / Q15768* / ephrin B3*ENSDARG0000004227748
efnb3a / ephrin-B3a / EFNB3* / Q15768* / O35393* / ephrin B3*ENSDARG0000011299347


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034255  Ephrin-B ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis ISS
 biological_processGO:0003404 optic vesicle morphogenesis IMP
 biological_processGO:0007155 cell adhesion ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0007412 axon target recognition IMP
 biological_processGO:0008039 synaptic target recognition IEP
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0021654 rhombomere boundary formation IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035475 angioblast cell migration involved in selective angioblast sprouting IMP
 biological_processGO:0048013 ephrin receptor signaling pathway ISS
 biological_processGO:0050920 regulation of chemotaxis ISS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0046875 ephrin receptor binding IBA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta aplastic , abnormal
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 ZFA:0000079 telencephalon telencephalon absent , abnormal
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 ZFA:0000114 heart heart decreased amount , abnormal
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 ZFA:0000713 abducens motor nucleus abducens motor nucleus fused with abducens motor nucleus , abnormal
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 ZFA:0000823 rhombomere 5 rhombomere 5 rhombomere boundary formation process quality , abnormal
rhombomere 5 deformed , abnormal
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 ZFA:0000948 rhombomere 3 rhombomere 3 rhombomere boundary formation process quality , abnormal
rhombomere 3 deformed , abnormal
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 ZFA:0001115 trunk trunk blood circulation decreased occurrence , abnormal
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 ZFA:0001117 post-vent region post-vent region blood circulation absent , abnormal
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 ZFA:0001286 caudal vein plexus caudal vein plexus increased size , abnormal
caudal vein plexus malformed , abnormal
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 ZFA:0001365 trigeminal motor nucleus trigeminal motor nucleus fused with trigeminal motor nucleus , abnormal
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 ZFA:0001462 somite border somite border malformed , abnormal
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 ZFA:0001678 immature eye immature eye cell migration disrupted , abnormal
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 ZFA:0005037 post-vent vasculature post-vent vasculature malformed , abnormal
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 ZFA:0005059 trabecular layer trabecular layer absent , abnormal
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 ZFA:0005877 commissure of the tract of the commissure of the caudal tuberculum commissure of the tract of the commissure of the caudal tuberculum has fewer parts of type commissure of the tract of the commissure of the caudal tuberculum axon, abnormal
commissure of the tract of the commissure of the caudal tuberculum commissural neuron axon guidance decreased process quality , abnormal
commissure of the tract of the commissure of the caudal tuberculum has extra parts of type commissure of the tract of the commissure of the caudal tuberculum axon, abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007723 efnb1 / ephrin-B1 / P52795* / P98172*  / - / complex / reaction
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / complex / reaction
 ENSDARG00000067916 lyn / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / complex
 ENSDARG00000035535 rasa1a / RAS p21 protein activator (GTPase activating protein) 1a / RASA1* / P20936* / RAS p21 protein activator 1*  / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSDARG00000073848 arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex / reaction
 ENSDARG00000021539 ephb2b / eph receptor B2b / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex / - / reaction
 ENSDARG00000005941 yes1 / clul1 / A1A5H8 / clusterin-like 1 (retinal) / P07947* / Q04736* / YES proto-oncogene 1, Src family tyrosine kinase*  / complex
 ENSDARG00000037870 actb2 / Q7ZVF9 / actin, beta 2 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / reaction / complex
 ENSDARG00000076757 ephb1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / - / reaction / complex
 ENSDARG00000037746 actb1 / Q7ZVI7 / actin, beta 1 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000037373 ephb2a / eph receptor B2a / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / reaction / complex / -
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex
 ENSDARG00000020164 efnb2a / O73874 / ephrin-B2a / EFNB2* / P52799* / P52800* / ephrin B2*  / reaction / complex / -
 ENSDARG00000030097 sdcbp / syndecan binding protein (syntenin) / O00560* / O08992* / syndecan binding protein*  / reaction / complex
 ENSDARG00000025326 myl12.2 / myosin, light chain 12, genome duplicate 2 / Q3THE2* / MYL12A* / MYL12B* / O14950* / P19105* / myosin light chain 12A* / myosin light chain 12B* / Myosin regulatory light chain 12B *  / reaction
 ENSDARG00000042277 efnb3b / ephrin-B3b / EFNB3* / Q15768* / ephrin B3*  / reaction / complex / -
 ENSDARG00000060415 arhgef28 / Rho guanine nucleotide exchange factor (GEF) 28 / Q8N1W1* / Rho guanine nucleotide exchange factor 28*  / reaction / complex
 ENSDARG00000039489 git1 / G protein-coupled receptor kinase interacting ArfGAP 1 / Q68FF6* / Q9Y2X7* / GIT ArfGAP 1* / ARF GTPase-activating protein GIT1 *  / reaction / complex
 ENSDARG00000043361 nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / reaction / complex
 ENSDARG00000074050 efnb2b / ephrin-B2b / EFNB2* / P52800* / P52799* / ephrin B2*  / reaction / complex / -
 ENSDARG00000075962 vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSDARG00000018206 nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000006299 arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / reaction / complex
 ENSDARG00000073665 rasa1b / RAS p21 protein activator (GTPase activating protein) 1b / RASA1* / P20936* / RAS p21 protein activator 1*  / complex
 ENSDARG00000112993 efnb3a / ephrin-B3a / EFNB3* / Q15768* / O35393* / ephrin B3*  / complex / - / reaction
 ENSDARG00000030376 grin2bb / glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b / GRIN2B* / Q13224* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)* / glutamate ionotropic recept...  / complex
 ENSDARG00000044718 vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*  / complex / reaction






 

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