ENSDARG00000039489


Danio rerio

Features
Gene ID: ENSDARG00000039489
  
Biological name :git1
  
Synonyms : git1 / G protein-coupled receptor kinase interacting ArfGAP 1
  
Possible biological names infered from orthology : ARF GTPase-activating protein GIT1 / GIT ArfGAP 1 / Q68FF6 / Q9Y2X7
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 28431621
Gene end: 28480576
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000057695
Ensembl peptide - ENSDARP00000137638
NCBI entrez gene - 568935     See in Manteia.
RefSeq - XM_005157670
RefSeq - XM_692294
swissprot - E7FAZ2
swissprot - A0A0R4IPR8
ZFIN ID - ZDB-GENE-100408-5
Ensembl - ENSDARG00000039489
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GIT1ENSGALG00000023703Gallus gallus
 GIT1ENSG00000108262Homo sapiens
 Git1ENSMUSG00000011877Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
git2b / G protein-coupled receptor kinase interacting ArfGAP 2b / GIT2* / Q14161* / Q9JLQ2* / GIT ArfGAP 2* / ARF GTPase-activating protein GIT2 *ENSDARG0000004279161
git2a / G protein-coupled receptor kinase interacting ArfGAP 2a / GIT2* / Q14161* / Q9JLQ2* / GIT ArfGAP 2* / ARF GTPase-activating protein GIT2 *ENSDARG0000006191561


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR002110  Ankyrin repeat
 IPR013724  GIT, Spa2 homology (SHD) domain
 IPR020683  Ankyrin repeat-containing domain
 IPR022018  ARF GTPase-activating protein GIT1, C-terminal
 IPR032352  Arf GTPase-activating protein GIT1/2, coiled-coil domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ephrin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
brain hemorrhagic , abnormal
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 ZFA:0000099 brain vasculature brain vasculature has fewer parts of type central artery , abnormal
brain vasculature broken , abnormal
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 ZFA:0005020 central artery central artery morphology , abnormal
central artery irregular spatial pattern , abnormal
central artery decreased length , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000073848 arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / reaction / complex
 ENSDARG00000076757 ephb1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex / reaction
 ENSDARG00000074050 efnb2b / ephrin-B2b / EFNB2* / P52800* / P52799* / ephrin B2*  / reaction / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000043361 nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / reaction / complex
 ENSDARG00000112993 efnb3a / ephrin-B3a / EFNB3* / Q15768* / O35393* / ephrin B3*  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / reaction / complex
 ENSDARG00000018206 nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / reaction / complex
 ENSDARG00000021539 ephb2b / eph receptor B2b / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / reaction / complex
 ENSDARG00000042277 efnb3b / ephrin-B3b / EFNB3* / Q15768* / ephrin B3*  / reaction / complex
 ENSDARG00000037373 ephb2a / eph receptor B2a / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex / reaction
 ENSDARG00000025326 myl12.2 / myosin, light chain 12, genome duplicate 2 / Q3THE2* / MYL12A* / MYL12B* / O14950* / P19105* / myosin light chain 12A* / myosin light chain 12B* / Myosin regulatory light chain 12B *  / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000020164 efnb2a / O73874 / ephrin-B2a / EFNB2* / P52799* / P52800* / ephrin B2*  / reaction / complex
 ENSDARG00000007723 efnb1 / ephrin-B1 / P52795* / P98172*  / reaction / complex
 ENSDARG00000006299 arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / reaction / complex






 

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