ENSMUSG00000011877


Mus musculus

Features
Gene ID: ENSMUSG00000011877
  
Biological name :Git1
  
Synonyms : ARF GTPase-activating protein GIT1 / Git1 / Q68FF6
  
Possible biological names infered from orthology : GIT ArfGAP 1 / Q9Y2X7
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 77493562
Gene end: 77507786
  
Corresponding Affymetrix probe sets: 10378870 (MoGene1.0st)   1454759_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037210
Ensembl peptide - ENSMUSP00000098375
NCBI entrez gene - 216963     See in Manteia.
MGI - MGI:1927140
RefSeq - XM_006532949
RefSeq - NM_001004144
RefSeq Peptide - NP_001004144
swissprot - Q5F258
swissprot - Q68FF6
Ensembl - ENSMUSG00000011877
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 git1ENSDARG00000039489Danio rerio
 GIT1ENSGALG00000023703Gallus gallus
 GIT1ENSG00000108262Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Git2 / Q9JLQ2 / ARF GTPase-activating protein GIT2 / Q14161* / GIT ArfGAP 2*ENSMUSG0000004189065


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR002110  Ankyrin repeat
 IPR013724  GIT, Spa2 homology (SHD) domain
 IPR020683  Ankyrin repeat-containing domain
 IPR022018  ARF GTPase-activating protein GIT1, C-terminal
 IPR032352  Arf GTPase-activating protein GIT1/2, coiled-coil domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001771 immunological synapse formation ISO
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0060996 dendritic spine development ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005925 focal adhesion IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ephrin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hsf2tm1Mmr/Hsf2tm1Mmr
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Hsf2tm1Mmr/Hsf2tm1Mmr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Acvr1btm1.1Gsu/Acvr1btm1.1Gsu,Tg(KRT14-cre)8Brn/Tg(KRT14-cre)8Brn
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Acvr1btm1.1Gsu/Acvr1btm1.1Gsu,Tg(KRT14-cre)8Brn/Tg(KRT14-cre)8Brn
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002803 abnormal operant conditional behavior "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0003460 decreased fear-related response "reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Hsf2tm1Mmr/Hsf2tm1Mmr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006057 decreased vascular endothelial cell number "less than normal number of cells lining the vasculature" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: B6.Cg-Ltb/Tnf/Ltatm1Dvk

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsf2tm1Mmr/Hsf2tm1Mmr
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Git1tm1Bcb/Git1tm1Bcb
Genetic Background: involves: 129 * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsf2tm1Mmr/Hsf2tm1Mmr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsf2tm1Mmr/Hsf2tm1Mmr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Git1tm1Bcb/Git1tm1Bcb
Genetic Background: involves: 129 * C57BL/6

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Git1tm1Bcb/Git1tm1Bcb
Genetic Background: involves: 129 * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Git1tm1Bcb/Git1tm1Bcb
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Git1Gt(FHCRC-GT-S10-12C1)Sor/Git1Gt(FHCRC-GT-S10-12C1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Git1tm1Bcb/Git1tm1Bcb
Genetic Background: involves: 129 * C57BL/6

 MP:0020316 decreased vascular endothelial cell proliferation "decrease in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Git1tm1Bcb/Git1tm1Bcb
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / reaction / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / reaction / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / reaction / complex
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex / reaction
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex / reaction
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / reaction / complex
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / reaction / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / complex / reaction
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex






 

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