ENSMUSG00000041890


Mus musculus

Features
Gene ID: ENSMUSG00000041890
  
Biological name :Git2
  
Synonyms : ARF GTPase-activating protein GIT2 / Git2 / Q9JLQ2
  
Possible biological names infered from orthology : GIT ArfGAP 2 / Q14161
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 114727407
Gene end: 114775517
  
Corresponding Affymetrix probe sets: 10532865 (MoGene1.0st)   1423391_at (Mouse Genome 430 2.0 Array)   1432160_at (Mouse Genome 430 2.0 Array)   1435925_at (Mouse Genome 430 2.0 Array)   1445037_at (Mouse Genome 430 2.0 Array)   1459283_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118812
Ensembl peptide - ENSMUSP00000116722
Ensembl peptide - ENSMUSP00000122302
Ensembl peptide - ENSMUSP00000136796
Ensembl peptide - ENSMUSP00000039718
Ensembl peptide - ENSMUSP00000083754
Ensembl peptide - ENSMUSP00000107801
Ensembl peptide - ENSMUSP00000107803
Ensembl peptide - ENSMUSP00000115185
Ensembl peptide - ENSMUSP00000115988
NCBI entrez gene - 26431     See in Manteia.
MGI - MGI:1347053
RefSeq - XM_017320893
RefSeq - NM_001077359
RefSeq - NM_001077360
RefSeq - NM_019834
RefSeq - XM_006530331
RefSeq - XM_006530332
RefSeq - XM_006530333
RefSeq - XM_006530334
RefSeq - XM_006530335
RefSeq - XM_006530336
RefSeq - XM_006530337
RefSeq - XM_006530338
RefSeq - XM_006530339
RefSeq - XM_017320892
RefSeq Peptide - NP_062808
RefSeq Peptide - NP_001070827
RefSeq Peptide - NP_001070828
RefSeq Peptide - NP_001334329
swissprot - F6WV69
swissprot - F7BIK4
swissprot - J3QK07
swissprot - D3Z409
swissprot - Q80XR8
swissprot - Q9JLQ2
swissprot - D3Z1I2
swissprot - E9PVA6
swissprot - F6SLJ2
swissprot - F6U8T2
Ensembl - ENSMUSG00000041890
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 git2aENSDARG00000061915Danio rerio
 git2bENSDARG00000042791Danio rerio
 GIT2ENSGALG00000040844Gallus gallus
 GIT2ENSG00000139436Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Git1 / Q68FF6 / ARF GTPase-activating protein GIT1 / Q9Y2X7* / GIT ArfGAP 1*ENSMUSG0000001187766


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR002110  Ankyrin repeat
 IPR013724  GIT, Spa2 homology (SHD) domain
 IPR020683  Ankyrin repeat-containing domain
 IPR022018  ARF GTPase-activating protein GIT1, C-terminal
 IPR032352  Arf GTPase-activating protein GIT1/2, coiled-coil domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048266 behavioral response to pain IMP
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Soat2tm1Far/Soat2tm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0002333 abnormal lung compliance "anomalous pulmonary volume change per unit pressure change " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002415 abnormal neutrophil morphology/development "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Git2Gt(XG510)Byg/Git2Gt(XG510)Byg,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Git2Gt(XG510)Byg/Git2Gt(XG510)Byg,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Git2Gt(XG510)Byg/Git2Gt(XG510)Byg,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Git2Gt(XG510)Byg/Git2Gt(XG510)Byg,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Genetic Background: C.129P2-Git2Gt(XG510)Byg

Allelic Composition: Git2Gt(XG510)Byg/Git2Gt(XG510)Byg,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Git2Gt(XG510)Byg/Git2Gt(XG510)Byg,Tg(DO11.10)10Dlo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Git2Gt(XG510)Byg/Git2Gt(XG510)Byg
Genetic Background: C.129P2-Git2Gt(XG510)Byg

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jak2tm1Kf/Jak2tm1Kf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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