ENSMUSG00000005958


Mus musculus

Features
Gene ID: ENSMUSG00000005958
  
Biological name :Ephb3
  
Synonyms : Ephb3 / Ephrin type-B receptor 3 / P54754
  
Possible biological names infered from orthology : EPH receptor B3 / P54753
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B1
Gene start: 21204755
Gene end: 21223305
  
Corresponding Affymetrix probe sets: 10434559 (MoGene1.0st)   1451550_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124375
Ensembl peptide - ENSMUSP00000006112
NCBI entrez gene - 13845     See in Manteia.
MGI - MGI:104770
RefSeq - NM_010143
RefSeq - XM_006521788
RefSeq Peptide - NP_034273
swissprot - E0CYA3
swissprot - P54754
Ensembl - ENSMUSG00000005958
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ephb3aENSDARG00000031548Danio rerio
 EPHB3ENSGALG00000008537Gallus gallus
 EPHB3ENSG00000182580Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*ENSMUSG0000003253770
Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*ENSMUSG0000002866469
Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*ENSMUSG0000002971058
Epha4 / Q03137 / Ephrin type-A receptor 4 / P54764* / EPH receptor A4*ENSMUSG0000002623556
Epha3 / EPH receptor A3 / P29320*ENSMUSG0000005250455
Epha7 / Q61772 / Ephrin type-A receptor 7 / Q15375* / EPH receptor A7*ENSMUSG0000002828955
Epha6 / EPH receptor A6 / Q9UF33*ENSMUSG0000005554053
Epha8 / O09127 / Ephrin type-A receptor 8 / P29322* / EPH receptor A8*ENSMUSG0000002866149
Ephb6 / O08644 / Ephrin type-B receptor 6 / EPH receptor B6*ENSMUSG0000002986947
Epha5 / Q60629 / Ephrin type-A receptor 5 / P54756* / EPH receptor A5*ENSMUSG0000002924547
Epha2 / Q03145 / Ephrin type-A receptor 2 ENSMUSG0000000644546
Epha1 / Q60750 / Ephrin type-A receptor 1 / P21709* / EPH receptor A1*ENSMUSG0000002985943


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034245  Ephrin type-B receptor 3, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001655 urogenital system development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IDA
 biological_processGO:0022038 corpus callosum development IMP
 biological_processGO:0022407 regulation of cell-cell adhesion IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IDA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0050770 regulation of axonogenesis IDA
 biological_processGO:0051965 positive regulation of synapse assembly IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060996 dendritic spine development IMP
 biological_processGO:0060997 dendritic spine morphogenesis IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity ISO
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008046 axon guidance receptor activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Bmgr4C57BL/6J/?,Ebmgr1129S6/SvEvTac/Ebmgr1129S6/SvEvTac,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm1Paw/Ephb2+,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2+,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ephb2tm1Paw/Ephb2+,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm4.1Jf/Ephb2tm4.1Jf,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmgr4C57BL/6J/?,Ebmgr1129S6/SvEvTac/Ebmgr1129S6/SvEvTac,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129/Sv * CD-1

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002946 delayed axon outgrowth "an increased amount of time required for an axon to extend from a neuron cell body and find the target" [J:77048, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003124 hypospadia "a urethral opening located closer to the base of the penis and not at the tip" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
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Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3+
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae

 MP:0004267 abnormal optic tract morphology "any structural anomaly of the band of optic nerve fibers running from the optic chiasma to the lateral geniculate body and midbrain" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129/Sv * CD-1

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004775 abnormal vestibular dark cell morphology "any structural abnormality in the nonsensory epithelial cells located above the vestibular melanocytes and adjacent to the sensory structures in the utricle and in the ampullae at the ends of each of the semicircular canals; these cells provide and maintain the high potassium ionic environment within the vestibular labyrinth and are therefore homologous to the marginal cells of the stria vascularis; they are joined to each other by tight junctions and provide a barrier between endolymph and perilymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004885 abnormal endolymph "any alteration in the normal production (volume) or ionic homeostasis of the fluid contained within the membranous labyrinth of the inner ear; unlike perilymph, endolymph resembles intracellular fluid in composition and has a high concentration of potassium ion and a low concentration of sodium ion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005189 abnormal anogenital distance "in comparison to the norm, aberration in the measure of the length of space from the genitals to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmgr4C57BL/6J/?,Ebmgr1129S6/SvEvTac/Ebmgr1129S6/SvEvTac,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb2tm1Paw/Ephb2+,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb2tm2.1Jf/Ephb2+,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb2tm2.1Jf/Ephb2tm2.1Jf,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb2tm4.1Jf/Ephb2+,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb2tm4.1Jf/Ephb2tm4.1Jf,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006389 abnormal vestibular endolymph "change in the normal production (volume) or ionic homeostasis of the fluid contained within the vestibule of the inner ear; unlike cochlear endolymph this fluid does not have a high potential" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006391 abnormal vestibular endolymph ionic homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of charged molecules in the vestibular endolymph" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008066 small endolymphatic duct "reduced size of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008960 abnormal axon pruning "defects in the developmental elimination of axons that fail to participate in an active neuronal circuit by retraction, degeneration, shedding or other mechanism" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmgr4C57BL/6J/?,Ebmgr1129S6/SvEvTac/Ebmgr1129S6/SvEvTac,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyrc-ch/Del(7)Tyrc-3H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0014077 ectopic Paneth cells "abnormal position of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex / reaction / -
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / complex / - / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / reaction / complex / -
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / - / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / complex
 ENSMUSG00000014932 Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*  / complex
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / reaction / complex / -
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / complex
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / - / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000022261 Sdc2 / P43407 / Syndecan-2 / P34741*  / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction / complex
 ENSMUSG00000011877 Git1 / Q68FF6 / ARF GTPase-activating protein GIT1 / Q9Y2X7* / GIT ArfGAP 1*  / complex / reaction
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / complex / reaction
 ENSMUSG00000028249 Sdcbp / O08992 / syndecan binding protein / O00560*  / complex / reaction
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / complex / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex / reaction / -
 ENSMUSG00000022957 Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*  / complex
 ENSMUSG00000061751 Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex
 ENSMUSG00000021662 Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*  / reaction / complex
 ENSMUSG00000021549 Rasa1 / RAS p21 protein activator 1 / P20936*  / complex






 

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