ENSMUSG00000029245


Mus musculus

Features
Gene ID: ENSMUSG00000029245
  
Biological name :Epha5
  
Synonyms : Epha5 / Ephrin type-A receptor 5 / Q60629
  
Possible biological names infered from orthology : EPH receptor A5 / P54756
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E1
Gene start: 84054761
Gene end: 84417382
  
Corresponding Affymetrix probe sets: 10530870 (MoGene1.0st)   1420557_at (Mouse Genome 430 2.0 Array)   1435286_at (Mouse Genome 430 2.0 Array)   1437920_at (Mouse Genome 430 2.0 Array)   1444690_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109030
Ensembl peptide - ENSMUSP00000109025
Ensembl peptide - ENSMUSP00000109033
Ensembl peptide - ENSMUSP00000109026
Ensembl peptide - ENSMUSP00000109028
Ensembl peptide - ENSMUSP00000060646
NCBI entrez gene - 13839     See in Manteia.
MGI - MGI:99654
RefSeq - XM_006534769
RefSeq - XM_006534770
RefSeq - XM_006534771
RefSeq - XM_006534773
RefSeq - XM_006534775
RefSeq - XM_017320657
RefSeq - NM_007937
RefSeq Peptide - NP_031963
swissprot - Q6PFV6
swissprot - E9PUQ2
swissprot - E9PUQ0
swissprot - E9PUP9
swissprot - Q60629
swissprot - E9PUQ4
Ensembl - ENSMUSG00000029245
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CT990561.1ENSDARG00000058284Danio rerio
 EPHA5ENSGALG00000011680Gallus gallus
 EPHA5ENSG00000145242Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epha3 / EPH receptor A3 / P29320*ENSMUSG0000005250464
Epha7 / Q61772 / Ephrin type-A receptor 7 / Q15375* / EPH receptor A7*ENSMUSG0000002828962
Epha4 / Q03137 / Ephrin type-A receptor 4 / P54764* / EPH receptor A4*ENSMUSG0000002623562
Epha6 / EPH receptor A6 / Q9UF33*ENSMUSG0000005554059
Epha8 / O09127 / Ephrin type-A receptor 8 / P29322* / EPH receptor A8*ENSMUSG0000002866155
Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*ENSMUSG0000003253754
Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*ENSMUSG0000000595854
Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*ENSMUSG0000002866454
Epha2 / Q03145 / Ephrin type-A receptor 2 ENSMUSG0000000644549
Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*ENSMUSG0000002971047
Epha1 / Q60750 / Ephrin type-A receptor 1 / P21709* / EPH receptor A1*ENSMUSG0000002985941
Ephb6 / O08644 / Ephrin type-B receptor 6 / EPH receptor B6*ENSMUSG0000002986939


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034277  Ephrin type-A receptor 5, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007162 negative regulation of cell adhesion ISO
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019933 cAMP-mediated signaling ISS
 biological_processGO:0021766 hippocampus development IDA
 biological_processGO:0032793 positive regulation of CREB transcription factor activity ISS
 biological_processGO:0032956 regulation of actin cytoskeleton organization IDA
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IDA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IDA
 biological_processGO:1904322 cellular response to forskolin IDA
 cellular_componentGO:0005791 rough endoplasmic reticulum ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Ercc5tm4Shm/Ercc5tm4Shm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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