ENSMUSG00000052504


Mus musculus

Features
Gene ID: ENSMUSG00000052504
  
Biological name :Epha3
  
Synonyms : Epha3 / EPH receptor A3
  
Possible biological names infered from orthology : P29320
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C1.3
Gene start: 63543538
Gene end: 63864158
  
Corresponding Affymetrix probe sets: 10440258 (MoGene1.0st)   1425574_at (Mouse Genome 430 2.0 Array)   1425575_at (Mouse Genome 430 2.0 Array)   1426057_a_at (Mouse Genome 430 2.0 Array)   1455426_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066554
NCBI entrez gene - 13837     See in Manteia.
MGI - MGI:99612
RefSeq - NM_010140
RefSeq Peptide - NP_034270
swissprot - Q8BRB1
Ensembl - ENSMUSG00000052504
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epha3ENSDARG00000039373Danio rerio
 EPHA3ENSGALG00000015403Gallus gallus
 EPHA3ENSG00000044524Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epha6 / EPH receptor A6 / Q9UF33*ENSMUSG0000005554063
Epha4 / Q03137 / Ephrin type-A receptor 4 / P54764* / EPH receptor A4*ENSMUSG0000002623563
Epha7 / Q61772 / Ephrin type-A receptor 7 / Q15375* / EPH receptor A7*ENSMUSG0000002828962
Epha5 / Q60629 / Ephrin type-A receptor 5 / P54756* / EPH receptor A5*ENSMUSG0000002924557
Epha8 / O09127 / Ephrin type-A receptor 8 / P29322* / EPH receptor A8*ENSMUSG0000002866156
Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*ENSMUSG0000000595856
Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*ENSMUSG0000002866455
Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*ENSMUSG0000003253755
Epha2 / Q03145 / Ephrin type-A receptor 2 ENSMUSG0000000644550
Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*ENSMUSG0000002971047
Epha1 / Q60750 / Ephrin type-A receptor 1 / P21709* / EPH receptor A1*ENSMUSG0000002985943
Ephb6 / O08644 / Ephrin type-B receptor 6 / EPH receptor B6*ENSMUSG0000002986941


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034266  Ephrin type-A receptor 3, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0045806 negative regulation of endocytosis IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0051893 regulation of focal adhesion assembly IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0006046 atrioventricular valve insufficiency "the atrioventricular valves do not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0006137 venoocclusion "blockage of blood flow through one or more veins" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0010592 abnormal atrioventricular septum morphology "any structural anomaly of the wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0010909 pulmonary alveolar hemorrhage "bleeding into the small sac-like dilations of the distal airspace of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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