ENSMUSG00000006445


Mus musculus

Features
Gene ID: ENSMUSG00000006445
  
Biological name :Epha2
  
Synonyms : Epha2 / Ephrin type-A receptor 2 / Q03145
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 141301240
Gene end: 141329384
  
Corresponding Affymetrix probe sets: 10509965 (MoGene1.0st)   1421151_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006614
NCBI entrez gene - 13836     See in Manteia.
MGI - MGI:95278
RefSeq - NM_010139
RefSeq - XM_006538528
RefSeq Peptide - NP_034269
swissprot - Q03145
Ensembl - ENSMUSG00000006445
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epha2aENSDARG00000017354Danio rerio
 epha2bENSDARG00000022727Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epha3 / EPH receptor A3 / P29320*ENSMUSG0000005250451
Epha4 / Q03137 / Ephrin type-A receptor 4 / P54764* / EPH receptor A4*ENSMUSG0000002623551
Epha6 / EPH receptor A6 / Q9UF33*ENSMUSG0000005554051
Epha7 / Q61772 / Ephrin type-A receptor 7 / Q15375* / EPH receptor A7*ENSMUSG0000002828950
Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*ENSMUSG0000002866448
Epha1 / Q60750 / Ephrin type-A receptor 1 / P21709* / EPH receptor A1*ENSMUSG0000002985948
Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*ENSMUSG0000003253747
Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*ENSMUSG0000000595847
Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*ENSMUSG0000002971046
Epha8 / O09127 / Ephrin type-A receptor 8 / P29322* / EPH receptor A8*ENSMUSG0000002866146
Epha5 / Q60629 / Ephrin type-A receptor 5 / P54756* / EPH receptor A5*ENSMUSG0000002924544
Ephb6 / O08644 / Ephrin type-B receptor 6 / EPH receptor B6*ENSMUSG0000002986938


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034263  Ephrin type-A receptor 2, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0001818 negative regulation of cytokine production IMP
 biological_processGO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage ISO
 biological_processGO:0010591 regulation of lamellipodium assembly ISS
 biological_processGO:0014028 notochord formation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030216 keratinocyte differentiation ISO
 biological_processGO:0030316 osteoclast differentiation IDA
 biological_processGO:0032682 negative regulation of chemokine production IMP
 biological_processGO:0033598 mammary gland epithelial cell proliferation IMP
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin ISO
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0043491 protein kinase B signaling ISO
 biological_processGO:0043535 regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0045765 regulation of angiogenesis IDA
 biological_processGO:0046058 cAMP metabolic process ISO
 biological_processGO:0046849 bone remodeling IMP
 biological_processGO:0048013 ephrin receptor signaling pathway IMP
 biological_processGO:0048320 axial mesoderm formation IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048570 notochord morphogenesis IMP
 biological_processGO:0048870 cell motility ISO
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling ISS
 biological_processGO:0060035 notochord cell development IMP
 biological_processGO:0060326 cell chemotaxis ISS
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IMP
 biological_processGO:0070309 lens fiber cell morphogenesis IDA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0070848 response to growth factor ISO
 biological_processGO:0090630 activation of GTPase activity ISO
 biological_processGO:1901491 negative regulation of lymphangiogenesis IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane ISO
 biological_processGO:1904238 pericyte cell differentiation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031256 leading edge membrane ISS
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity ISO
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vsx1tm1Bhr/Vsx1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Mc1re/Mc1re,Mlphln/Mlphln
Genetic Background: Not Specified

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Epha2tm1Jrui/Epha2tm1Jrui,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm2.1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * FVB/N

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Casq2tm1.1Sgp/Casq2tm1.1Sgp
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrL

 MP:0001684 abnormal axial mesoderm "malformed middle primary germ layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:51834]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hexbtm1Grv/Hexbtm1Grv
Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc1re/Mc1re,Mlphln/Mlphln
Genetic Background: Not Specified

Allelic Composition: Epha2Gt(KST085)Byg/Epha2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004713 split notochord "the appearance of an abnormal division in the axial fibrocellular cord in embryos around which develops the vertebral primordia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0006029 abnormal sclerotome "malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0010255 cortical cataracts "a lens opacity, frequently punctate, affecting the lens cortex in which spokes or wedges progressively extend from the outside of the lens towards the center" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Mc1re/Mc1re,Mlphln/Mlphln
Genetic Background: Not Specified

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epha2tm1Jrui/Epha2tm1Jrui,Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Trp53tm2.1Tyj/Trp53+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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