ENSMUSG00000028289


Mus musculus

Features
Gene ID: ENSMUSG00000028289
  
Biological name :Epha7
  
Synonyms : Epha7 / Ephrin type-A receptor 7 / Q61772
  
Possible biological names infered from orthology : EPH receptor A7 / Q15375
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A4
Gene start: 28813131
Gene end: 28967499
  
Corresponding Affymetrix probe sets: 10503659 (MoGene1.0st)   1427528_a_at (Mouse Genome 430 2.0 Array)   1443485_at (Mouse Genome 430 2.0 Array)   1451991_at (Mouse Genome 430 2.0 Array)   1452380_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029964
Ensembl peptide - ENSMUSP00000079735
Ensembl peptide - ENSMUSP00000103826
Ensembl peptide - ENSMUSP00000103829
NCBI entrez gene - 13841     See in Manteia.
MGI - MGI:95276
RefSeq - XM_017319955
RefSeq - NM_001122889
RefSeq - NM_001290434
RefSeq - NM_010141
RefSeq - XM_006537606
RefSeq - XM_006537607
RefSeq - XM_017319954
RefSeq Peptide - NP_001116361
RefSeq Peptide - NP_001277363
RefSeq Peptide - NP_034271
swissprot - Q61772
swissprot - Q8CC52
swissprot - A2BDQ4
Ensembl - ENSMUSG00000028289
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epha7ENSDARG00000004635Danio rerio
 EPHA7ENSGALG00000015593Gallus gallus
 EPHA7ENSG00000135333Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epha4 / Q03137 / Ephrin type-A receptor 4 / P54764* / EPH receptor A4*ENSMUSG0000002623562
Epha3 / EPH receptor A3 / P29320*ENSMUSG0000005250461
Epha6 / EPH receptor A6 / Q9UF33*ENSMUSG0000005554058
Epha8 / O09127 / Ephrin type-A receptor 8 / P29322* / EPH receptor A8*ENSMUSG0000002866157
Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*ENSMUSG0000003253756
Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*ENSMUSG0000002866456
Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*ENSMUSG0000000595855
Epha5 / Q60629 / Ephrin type-A receptor 5 / P54756* / EPH receptor A5*ENSMUSG0000002924555
Epha2 / Q03145 / Ephrin type-A receptor 2 ENSMUSG0000000644549
Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*ENSMUSG0000002971048
Epha1 / Q60750 / Ephrin type-A receptor 1 / P21709* / EPH receptor A1*ENSMUSG0000002985944
Ephb6 / O08644 / Ephrin type-B receptor 6 / EPH receptor B6*ENSMUSG0000002986942


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034283  Ephrin type-A receptor 7, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0022407 regulation of cell-cell adhesion IDA
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0031952 regulation of protein autophosphorylation IDA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IMP
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0048671 negative regulation of collateral sprouting IDA
 biological_processGO:0048755 branching morphogenesis of a nerve IMP
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051964 negative regulation of synapse assembly IDA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0072178 nephric duct morphogenesis IGI
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008046 axon guidance receptor activity IMP
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0045499 chemorepellent activity IDA
 molecular_functionGO:0046875 ephrin receptor binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001890 anencephaly "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571]
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Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: CrygsOpj/CrygsOpj
Genetic Background: involves: 102 * C3H/He * T STOCK

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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