ENSMUSG00000026235


Mus musculus

Features
Gene ID: ENSMUSG00000026235
  
Biological name :Epha4
  
Synonyms : Epha4 / Ephrin type-A receptor 4 / Q03137
  
Possible biological names infered from orthology : EPH receptor A4 / P54764
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C4
Gene start: 77367185
Gene end: 77515088
  
Corresponding Affymetrix probe sets: 10355893 (MoGene1.0st)   1421928_at (Mouse Genome 430 2.0 Array)   1421929_at (Mouse Genome 430 2.0 Array)   1429021_at (Mouse Genome 430 2.0 Array)   1439757_s_at (Mouse Genome 430 2.0 Array)   1456863_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140370
Ensembl peptide - ENSMUSP00000140954
Ensembl peptide - ENSMUSP00000140631
Ensembl peptide - ENSMUSP00000140408
Ensembl peptide - ENSMUSP00000027451
Ensembl peptide - ENSMUSP00000139640
NCBI entrez gene - 13838     See in Manteia.
MGI - MGI:98277
RefSeq - XM_006496408
RefSeq - NM_007936
RefSeq - XM_006496407
RefSeq Peptide - NP_031962
swissprot - A0A087WRH4
swissprot - Q03137
swissprot - A0A087WQW6
swissprot - A0A087WQZ6
Ensembl - ENSMUSG00000026235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epha4lENSDARG00000010767Danio rerio
 EPHA4ENSGALG00000005256Gallus gallus
 EPHA4ENSG00000116106Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epha3 / EPH receptor A3 / P29320*ENSMUSG0000005250463
Epha7 / Q61772 / Ephrin type-A receptor 7 / Q15375* / EPH receptor A7*ENSMUSG0000002828963
Epha6 / EPH receptor A6 / Q9UF33*ENSMUSG0000005554060
Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*ENSMUSG0000003253758
Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*ENSMUSG0000002866458
Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*ENSMUSG0000000595857
Epha8 / O09127 / Ephrin type-A receptor 8 / P29322* / EPH receptor A8*ENSMUSG0000002866156
Epha5 / Q60629 / Ephrin type-A receptor 5 / P54756* / EPH receptor A5*ENSMUSG0000002924555
Epha2 / Q03145 / Ephrin type-A receptor 2 ENSMUSG0000000644551
Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*ENSMUSG0000002971049
Epha1 / Q60750 / Ephrin type-A receptor 1 / P21709* / EPH receptor A1*ENSMUSG0000002985944
Ephb6 / O08644 / Ephrin type-B receptor 6 / EPH receptor B6*ENSMUSG0000002986943


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034270  Ephrin type-A receptor 4, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0008347 glial cell migration IEA
 biological_processGO:0010977 negative regulation of neuron projection development IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021957 corticospinal tract morphogenesis IMP
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IDA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048681 negative regulation of axon regeneration IEA
 biological_processGO:0048710 regulation of astrocyte differentiation IMP
 biological_processGO:0050770 regulation of axonogenesis IMP
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IMP
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IGI
 biological_processGO:0072178 nephric duct morphogenesis IGI
 biological_processGO:0097155 fasciculation of sensory neuron axon IMP
 biological_processGO:0097156 fasciculation of motor neuron axon IMP
 biological_processGO:0097485 neuron projection guidance IDA
 biological_processGO:0106030 neuron projection fasciculation IDA
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IGI
 biological_processGO:1902004 positive regulation of amyloid-beta formation IEA
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IEA
 biological_processGO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:1904646 cellular response to amyloid-beta IGI
 biological_processGO:1905244 regulation of modification of synaptic structure IEA
 biological_processGO:2001108 positive regulation of Rho guanyl-nucleotide exchange factor activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0031901 early endosome membrane IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISS
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IMP
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042731 PH domain binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0097161 DH domain binding IEA
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000860 abnormal primary somatosensory cortex morphology "any malformation or absence of the area of the postcentral gyrus and central sulcus that is involved in somatic sensation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm2Kln/Epha4tm2Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Epha4tm6Kln/Epha4tm6Kln
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Epha4tm1Byd/Epha4+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm2Kln/Epha4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Epha4tm5Kln/Epha4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Mybpc3tm1.1Jse/Mybpc3tm1.1Jse
Genetic Background: Not Specified

Allelic Composition: Epha4Gt(PST038)Byg/Epha4tm1Kldr
Genetic Background: involves: 129P2/OlaHsd

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4tm1.2Bzh/Epha4tm1.2Bzh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Epha4tm1.1Bzh/Epha4tm1.2Bzh,Tg(Hoxb8-cre)1403Uze/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Epha4tm1.1Bzh/Epha4tm1.2Bzh,Tg(Slc17a6-icre)1Oki/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: Epha4Gt(PST038)Byg/Epha4Gt(PST038)Byg,Rettm1.1Kln/Rettm1.1Kln
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * CBA/J

Allelic Composition: Epha4Gt(PST038)Byg/Epha4Gt(PST038)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb/Epha4rb
Genetic Background: B6 x STOCK Epha4rb/J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Mybpc3tm1.1Jse/Mybpc3tm1.1Jse
Genetic Background: Not Specified

Allelic Composition: Epha4rb/Epha4rb
Genetic Background: B6 x STOCK Epha4rb/J

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Epha4tm2Kln/Epha4tm2Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Epha4tm3Kln/Epha4tm3Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Epha4Gt(PST038)Byg/Epha4Gt(PST038)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Chn1Gt714Lex/Chn1+,Epha4tm1Pch/Epha4+
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

Allelic Composition: Epha4tm2Kldr/Epha4tm2Kldr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Epha4tm1Bzh/Epha4tm1Bzh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Epha4tm1.2Bzh/Epha4tm1.2Bzh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Allelic Composition: Epha4tm1.1Bzh/Epha4tm1.2Bzh,Tg(Hoxb8-cre)1403Uze/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Epha4tm1.1Bzh/Epha4tm1.2Bzh,Tg(Slc17a6-icre)1Oki/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Lpar1tm1Mcox/Lpar1tm1Mcox
Genetic Background: B6.129P2-Lpar1tm1Mcox

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4m1Btlr/Epha4m1Btlr
Genetic Background: C57BL/6J-Epha4m1Btlr

 MP:0001526 abnormal placing response "altered ability to stretch and lift the forelimbs and head to grab a close edge " [J:66943, MGI:cml]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Epha4rb/Epha4rb
Genetic Background: B6 x STOCK Epha4rb/J

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4tm1Kldr/Epha4tm1Kldr
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Epha4tm1.1Bzh/Epha4tm1.1Bzh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm2Kln/Epha4tm2Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Epha4tm6Kln/Epha4tm6Kln
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Epha4tm1Byd/Epha4+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm2Kln/Epha4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Epha4tm5Kln/Epha4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4rb/Epha4rb
Genetic Background: B6 x STOCK Epha4rb/J

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0002878 abnormal corticospinal tract "anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mybpc3tm1.1Jse/Mybpc3tm1.1Jse
Genetic Background: Not Specified

Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Epha4tm3Kln/Epha4tm3Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Epha4Gt(PST038)Byg/Epha4Gt(PST038)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Epha4Gt(PST038)Byg/Epha4tm1Kldr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Epha4tm1.1Bzh/Epha4tm1.2Bzh,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Epha4tm1.1Bzh/Epha4tm1.2Bzh,Tg(Slc17a6-icre)1Oki/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Epha4Gt(PST038)Byg/Epha4Gt(PST038)Byg,Rettm1.1Kln/Rettm1.1Kln
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * CBA/J

Allelic Composition: Epha4Gt(PST038)Byg/Epha4Gt(PST038)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003477 abnormal nerve fiber response "anomaly in the electrophysiological recordings from a single or several nerve fiber(s)" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Epha4tm1.1Bzh/Epha4tm1.2Bzh,Tg(Slc17a6-icre)1Oki/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003880 abnormal central pattern generator function "anomalous function of the neural networks that produce rhythmic patterned output without sensory input and underlie rhythmic motor patterns" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:101019]
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Allelic Composition: Mybpc3tm1.1Jse/Mybpc3tm1.1Jse
Genetic Background: Not Specified

Allelic Composition: Epha4tm6Kln/Epha4tm6Kln
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Epha4tm1Kldr/Epha4tm1Kldr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003989 abnormal barrel cortex morphology "malformation of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm2Kln/Epha4tm2Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Epha4tm6Kln/Epha4tm6Kln
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Epha4tm1Byd/Epha4+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm2Kln/Epha4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Epha4tm5Kln/Epha4+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chn1Gt714Lex/Chn1+,Epha4tm1Pch/Epha4+
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2tm4.1Skn/Sox2tm4.1Skn,Tg(Sox2-cre/ERT2)1Skn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Efnb3tm1Henk/Efnb3tm1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm1Kldr/Epha4tm1Kldr
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Epha4Gt(PST038)Byg/Epha4Gt(PST038)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Epha4tm2Kldr/Epha4tm2Kldr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009677 abnormal spinal cord dorsal column morphology "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm2Kln/Epha4tm2Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Epha4tm1Kldr/Epha4tm1Kldr
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Chn1Gt714Lex/Chn1+,Epha4tm1Pch/Epha4+
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

Allelic Composition: Epha4tm2Kldr/Epha4tm2Kldr,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Epha4tm1.2Bzh/Epha4tm1.2Bzh
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Epha4tm1.1Bzh/Epha4tm1.2Bzh,Tg(Hoxb8-cre)1403Uze/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Epha4tm1.1Bzh/Epha4tm1.2Bzh,Tg(Slc17a6-icre)1Oki/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Epha4rb/Epha4rb
Genetic Background: B6 x STOCK Epha4rb/J

Allelic Composition: Epha4rb-2J/Epha4rb-2J
Genetic Background: C57BL/6J-Epha4rb-2J/GrsrJ

 MP:0010859 abnormal anterior commissure pars anterior morphology "any structural anomaly of the small horseshoe-shaped anterior part of the anterior commissure which pass into the two olfactory bulbs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm1Kldr/Epha4tm1Kldr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010860 abnormal anterior commissure pars posterior morphology "any structural anomaly of the large posterior part of the anterior commissure which connects the right and left temporal lobes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Epha4tm1Kldr/Epha4tm1Kldr
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0020529 ectopic thalamus "abnormal position of the thalamus" [] {def="MGI:smb"}
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Allelic Composition: Epha4tm6Kln/Epha4tm6Kln
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Epha4tm5Kln/Epha4tm5Kln
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Epha4tm1Kldr/Epha4tm1Kldr
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026259 Ngef / Q8CHT1 / Ephexin-1 / Q8N5V2* / neuronal guanine nucleotide exchange factor*  / complex / reaction






 

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