ENSGALG00000005256


Gallus gallus

Features
Gene ID: ENSGALG00000005256
  
Biological name :EPHA4
  
Synonyms : EPHA4 / ephrin type-A receptor 4 precursor
  
Possible biological names infered from orthology : EPH receptor A4 / Ephrin type-A receptor 4 / P54764 / Q03137
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 7630571
Gene end: 7841500
  
Corresponding Affymetrix probe sets: Gga.304.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000008426
Ensembl peptide - ENSGALP00000057258
Ensembl peptide - ENSGALP00000054490
NCBI entrez gene - 395559     See in Manteia.
RefSeq - XM_015276814
RefSeq - XM_015276816
RefSeq - XM_015276815
RefSeq - NM_204781
RefSeq Peptide - NP_990112
swissprot - A0A1I7Q3Z3
swissprot - A0A1D5PNP7
swissprot - A0A1D5PWC7
Ensembl - ENSGALG00000005256
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epha4lENSDARG00000010767Danio rerio
 EPHA4ENSG00000116106Homo sapiens
 Epha4ENSMUSG00000026235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHA5 / ephrin type-A receptor 5 precursor / Q60629* / P54756* / EPH receptor A5* / Ephrin type-A receptor 5 *ENSGALG0000001168064
EPHA7 / O42422 / Ephrin type-A receptor 7 / Q15375* / Q61772* / EPH receptor A7*ENSGALG0000001559362
EPHA3 / ephrin type-A receptor 3 precursor / P29320* / EPH receptor A3*ENSGALG0000001540362
EPHA8 / EPH receptor A8 / O09127* / P29322* / Ephrin type-A receptor 8 *ENSGALG0000002156759
EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *ENSGALG0000000660958
EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *ENSGALG0000000474157
EPHB3 / EPH receptor B3 / P54753* / P54754* / Ephrin type-B receptor 3 *ENSGALG0000000853755
EPHB6 / ephrin type-B receptor 5 precursor / O08644* / EPH receptor B6* / Ephrin type-B receptor 6 *ENSGALG0000001474951
EPHA6 / EPH receptor A6 / Q9UF33*ENSGALG0000001541841


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007628 adult walking behavior IEA
 biological_processGO:0008045 motor neuron axon guidance IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021957 corticospinal tract morphogenesis IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048681 negative regulation of axon regeneration IEA
 biological_processGO:0048710 regulation of astrocyte differentiation IEA
 biological_processGO:0050770 regulation of axonogenesis IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0072178 nephric duct morphogenesis IEA
 biological_processGO:0097155 fasciculation of sensory neuron axon IEA
 biological_processGO:0097156 fasciculation of motor neuron axon IEA
 biological_processGO:0097485 neuron projection guidance IEA
 biological_processGO:0106030 neuron projection fasciculation IEA
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IEA
 biological_processGO:1902004 positive regulation of amyloid-beta formation IEA
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IEA
 biological_processGO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1905244 regulation of modification of synaptic structure IEA
 biological_processGO:2001108 positive regulation of Rho guanyl-nucleotide exchange factor activity IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IEA
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042731 PH domain binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0097161 DH domain binding IEA
 molecular_functionGO:1990782 protein tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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