ENSGALG00000021567


Gallus gallus

Features
Gene ID: ENSGALG00000021567
  
Biological name :EPHA8
  
Synonyms : EPHA8 / EPH receptor A8
  
Possible biological names infered from orthology : Ephrin type-A receptor 8 / O09127 / P29322
  
Species: Gallus gallus
  
Chr. number: 21
Strand: -1
Band:
Gene start: 6128022
Gene end: 6154299
  
Corresponding Affymetrix probe sets: GgaAffx.2942.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000007542
NCBI entrez gene - 428198     See in Manteia.
RefSeq - XM_015297218
swissprot - F1NHC6
Ensembl - ENSGALG00000021567
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EPHA8ENSG00000070886Homo sapiens
 Epha8ENSMUSG00000028661Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHA5 / ephrin type-A receptor 5 precursor / Q60629* / P54756* / EPH receptor A5* / Ephrin type-A receptor 5 *ENSGALG0000001168060
EPHA4 / ephrin type-A receptor 4 precursor / Q03137* / P54764* / EPH receptor A4* / Ephrin type-A receptor 4 *ENSGALG0000000525660
EPHA7 / O42422 / Ephrin type-A receptor 7 / Q15375* / Q61772* / EPH receptor A7*ENSGALG0000001559360
EPHA3 / ephrin type-A receptor 3 precursor / P29320* / EPH receptor A3*ENSGALG0000001540359
EPHB3 / EPH receptor B3 / P54753* / P54754* / Ephrin type-B receptor 3 *ENSGALG0000000853752
EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *ENSGALG0000000474152
EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *ENSGALG0000000660952
EPHB6 / ephrin type-B receptor 5 precursor / O08644* / EPH receptor B6* / Ephrin type-B receptor 6 *ENSGALG0000001474948
EPHA6 / EPH receptor A6 / Q9UF33*ENSGALG0000001541840


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020691  Ephrin type-A receptor 8
 IPR027936  Ephrin receptor, transmembrane domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006929 substrate-dependent cell migration IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016322 neuron remodeling IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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