ENSG00000070886


Homo sapiens

Features
Gene ID: ENSG00000070886
  
Biological name :EPHA8
  
Synonyms : EPHA8 / EPH receptor A8 / P29322
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.12
Gene start: 22563564
Gene end: 22603594
  
Corresponding Affymetrix probe sets: 1554069_at (Human Genome U133 Plus 2.0 Array)   231796_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000166244
Ensembl peptide - ENSP00000363775
NCBI entrez gene - 2046     See in Manteia.
OMIM - 176945
RefSeq - XM_011540975
RefSeq - NM_001006943
RefSeq - NM_020526
RefSeq - XM_011540970
RefSeq - XM_011540972
RefSeq - XM_011540973
RefSeq - XM_011540969
RefSeq Peptide - NP_065387
RefSeq Peptide - NP_001006944
swissprot - P29322
Ensembl - ENSG00000070886
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EPHA8ENSGALG00000021567Gallus gallus
 Epha8ENSMUSG00000028661Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHA5 / P54756 / EPH receptor A5ENSG0000014524258
EPHA7 / Q15375 / EPH receptor A7ENSG0000013533357
EPHA4 / P54764 / EPH receptor A4ENSG0000011610656
EPHA3 / P29320 / EPH receptor A3ENSG0000004452455
EPHA6 / Q9UF33 / EPH receptor A6ENSG0000008022455
EPHB1 / P54762 / EPH receptor B1ENSG0000015492851
EPHB2 / P29323 / EPH receptor B2ENSG0000013321650
EPHB3 / P54753 / EPH receptor B3ENSG0000018258050
EPHB4 / P54760 / EPH receptor B4ENSG0000019641145
EPHA1 / P21709 / EPH receptor A1ENSG0000014690440
EPHB6 / EPH receptor B6ENSG0000010612340


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020691  Ephrin type-A receptor 8
 IPR027936  Ephrin receptor, transmembrane domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006929 substrate-dependent cell migration IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016322 neuron remodeling IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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