ENSG00000106123


Homo sapiens

Features
Gene ID: ENSG00000106123
  
Biological name :EPHB6
  
Synonyms : EPHB6 / EPH receptor B6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q34
Gene start: 142855061
Gene end: 142871094
  
Corresponding Affymetrix probe sets: 204718_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477807
Ensembl peptide - ENSP00000409061
Ensembl peptide - ENSP00000481994
Ensembl peptide - ENSP00000482735
Ensembl peptide - ENSP00000481996
Ensembl peptide - ENSP00000404786
NCBI entrez gene - 2051     See in Manteia.
OMIM - 602757
RefSeq - XM_011515882
RefSeq - NM_001280794
RefSeq - NM_001280795
RefSeq - NM_004445
RefSeq - XM_006715881
RefSeq - XM_011515879
RefSeq - XM_011515880
RefSeq - XM_011515881
RefSeq Peptide - NP_001267724
RefSeq Peptide - NP_004436
RefSeq Peptide - NP_001267723
swissprot - F8WCM8
swissprot - J3KQU5
swissprot - A0A087WTE3
swissprot - A0A087WZL4
swissprot - A0A087WYP8
Ensembl - ENSG00000106123
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ephb6ENSDARG00000057729Danio rerio
 EPHB6ENSGALG00000014749Gallus gallus
 Ephb6ENSMUSG00000029869Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHB1 / P54762 / EPH receptor B1ENSG0000015492847
EPHB2 / P29323 / EPH receptor B2ENSG0000013321646
EPHB3 / P54753 / EPH receptor B3ENSG0000018258046
EPHB4 / P54760 / EPH receptor B4ENSG0000019641141
EPHA4 / P54764 / EPH receptor A4ENSG0000011610641
EPHA7 / Q15375 / EPH receptor A7ENSG0000013533341
EPHA6 / Q9UF33 / EPH receptor A6ENSG0000008022440
EPHA5 / P54756 / EPH receptor A5ENSG0000014524240
EPHA8 / P29322 / EPH receptor A8ENSG0000007088639
EPHA3 / P29320 / EPH receptor A3ENSG0000004452439
EPHA1 / P21709 / EPH receptor A1ENSG0000014690436


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR027936  Ephrin receptor, transmembrane domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001806 type IV hypersensitivity IEA
 biological_processGO:0002456 T cell mediated immunity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0050663 cytokine secretion IEA
 biological_processGO:0050798 activated T cell proliferation IEA
 biological_processGO:2000525 positive regulation of T cell costimulation IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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