ENSG00000146904


Homo sapiens

Features
Gene ID: ENSG00000146904
  
Biological name :EPHA1
  
Synonyms : EPHA1 / EPH receptor A1 / P21709
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q35
Gene start: 143390289
Gene end: 143408892
  
Corresponding Affymetrix probe sets: 205977_s_at (Human Genome U133 Plus 2.0 Array)   215804_at (Human Genome U133 Plus 2.0 Array)   241482_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000275815
NCBI entrez gene - 2041     See in Manteia.
OMIM - 179610
RefSeq - NM_005232
RefSeq - XM_006715880
RefSeq Peptide - NP_005223
swissprot - P21709
Ensembl - ENSG00000146904
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Epha1ENSMUSG00000029859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHA7 / Q15375 / EPH receptor A7ENSG0000013533345
EPHB1 / P54762 / EPH receptor B1ENSG0000015492844
EPHA4 / P54764 / EPH receptor A4ENSG0000011610644
EPHA6 / Q9UF33 / EPH receptor A6ENSG0000008022443
EPHA5 / P54756 / EPH receptor A5ENSG0000014524243
EPHA3 / P29320 / EPH receptor A3ENSG0000004452443
EPHB3 / P54753 / EPH receptor B3ENSG0000018258043
EPHB2 / P29323 / EPH receptor B2ENSG0000013321642
EPHB4 / P54760 / EPH receptor B4ENSG0000019641141
EPHA8 / P29322 / EPH receptor A8ENSG0000007088641
EPHB6 / EPH receptor B6ENSG0000010612338


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034251  Ephrin type-A receptor 1, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IDA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IDA
 biological_processGO:0035019 somatic stem cell population maintenance TAS
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0090630 activation of GTPase activity IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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