ENSG00000080224


Homo sapiens

Features
Gene ID: ENSG00000080224
  
Biological name :EPHA6
  
Synonyms : EPHA6 / EPH receptor A6 / Q9UF33
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q11.2
Gene start: 96814581
Gene end: 97752460
  
Corresponding Affymetrix probe sets: 1561396_at (Human Genome U133 Plus 2.0 Array)   233184_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421353
Ensembl peptide - ENSP00000421260
Ensembl peptide - ENSP00000421711
Ensembl peptide - ENSP00000425132
Ensembl peptide - ENSP00000424638
Ensembl peptide - ENSP00000423950
Ensembl peptide - ENSP00000374323
Ensembl peptide - ENSP00000419470
Ensembl peptide - ENSP00000420598
NCBI entrez gene - 285220     See in Manteia.
OMIM - 600066
RefSeq - XM_017006223
RefSeq - XM_017006210
RefSeq - XM_017006211
RefSeq - XM_017006212
RefSeq - XM_017006213
RefSeq - XM_017006214
RefSeq - XM_017006216
RefSeq - XM_017006217
RefSeq - XM_017006218
RefSeq - XM_017006219
RefSeq - XM_017006220
RefSeq - XM_017006221
RefSeq - XM_017006222
RefSeq - NM_001080448
RefSeq - NM_001278300
RefSeq - NM_001278301
RefSeq - NM_173655
RefSeq - XM_006713592
RefSeq Peptide - NP_001265229
RefSeq Peptide - NP_001265230
RefSeq Peptide - NP_775926
RefSeq Peptide - NP_001073917
swissprot - H0Y9V0
swissprot - J3KR66
swissprot - A0A0B4J1T8
swissprot - E7EU71
swissprot - Q9UF33
swissprot - B4DXQ6
swissprot - B4DXM2
swissprot - H0Y8K5
Ensembl - ENSG00000080224
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epha6ENSDARG00000022971Danio rerio
 EPHA6ENSGALG00000015418Gallus gallus
 Epha6ENSMUSG00000055540Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHA3 / P29320 / EPH receptor A3ENSG0000004452455
EPHA5 / P54756 / EPH receptor A5ENSG0000014524254
EPHA4 / P54764 / EPH receptor A4ENSG0000011610653
EPHA7 / Q15375 / EPH receptor A7ENSG0000013533352
EPHA8 / P29322 / EPH receptor A8ENSG0000007088649
EPHB3 / P54753 / EPH receptor B3ENSG0000018258047
EPHB2 / P29323 / EPH receptor B2ENSG0000013321647
EPHB1 / P54762 / EPH receptor B1ENSG0000015492847
EPHB4 / P54760 / EPH receptor B4ENSG0000019641142
EPHA1 / P21709 / EPH receptor A1ENSG0000014690437
EPHB6 / EPH receptor B6ENSG0000010612336


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034280  Ephrin type-A receptor 6, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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