ENSG00000154928


Homo sapiens

Features
Gene ID: ENSG00000154928
  
Biological name :EPHB1
  
Synonyms : EPHB1 / EPH receptor B1 / P54762
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q22.2
Gene start: 134597801
Gene end: 135260467
  
Corresponding Affymetrix probe sets: 210753_s_at (Human Genome U133 Plus 2.0 Array)   211898_s_at (Human Genome U133 Plus 2.0 Array)   230425_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417216
Ensembl peptide - ENSP00000420338
Ensembl peptide - ENSP00000419688
Ensembl peptide - ENSP00000419574
Ensembl peptide - ENSP00000418352
Ensembl peptide - ENSP00000417435
Ensembl peptide - ENSP00000381097
NCBI entrez gene - 2047     See in Manteia.
OMIM - 600600
RefSeq - XM_017005868
RefSeq - NM_004441
RefSeq - XM_011512542
RefSeq - XM_017005866
RefSeq - XM_017005867
RefSeq Peptide - NP_004432
swissprot - P54762
swissprot - C9K090
swissprot - C9J466
swissprot - C9JB88
swissprot - F8WDG5
swissprot - C9J6S4
Ensembl - ENSG00000154928
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ephb1ENSDARG00000076757Danio rerio
 EPHB1ENSGALG00000006609Gallus gallus
 Ephb1ENSMUSG00000032537Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHB2 / P29323 / EPH receptor B2ENSG0000013321673
EPHB3 / P54753 / EPH receptor B3ENSG0000018258070
EPHA4 / P54764 / EPH receptor A4ENSG0000011610658
EPHA7 / Q15375 / EPH receptor A7ENSG0000013533357
EPHA5 / P54756 / EPH receptor A5ENSG0000014524257
EPHB4 / P54760 / EPH receptor B4ENSG0000019641156
EPHA3 / P29320 / EPH receptor A3ENSG0000004452455
EPHA6 / Q9UF33 / EPH receptor A6ENSG0000008022454
EPHA8 / P29322 / EPH receptor A8ENSG0000007088652
EPHB6 / EPH receptor B6ENSG0000010612348
EPHA1 / P21709 / EPH receptor A1ENSG0000014690443


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034231  Ephrin type-B receptor 1, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0001771 immunological synapse formation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance ISS
 biological_processGO:0014719 skeletal muscle satellite cell activation ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021545 cranial nerve development IEA
 biological_processGO:0021631 optic nerve morphogenesis IEA
 biological_processGO:0021952 central nervous system projection neuron axonogenesis ISS
 biological_processGO:0022008 neurogenesis ISS
 biological_processGO:0030010 establishment of cell polarity ISS
 biological_processGO:0031290 retinal ganglion cell axon guidance ISS
 biological_processGO:0031589 cell-substrate adhesion IDA
 biological_processGO:0046328 regulation of JNK cascade IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain ISS
 biological_processGO:0051965 positive regulation of synapse assembly ISS
 biological_processGO:0060326 cell chemotaxis IDA
 biological_processGO:0060996 dendritic spine development ISS
 biological_processGO:0060997 dendritic spine morphogenesis ISS
 biological_processGO:0061351 neural precursor cell proliferation ISS
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:1901214 regulation of neuron death IMP
 biological_processGO:1902723 negative regulation of skeletal muscle satellite cell proliferation ISS
 biological_processGO:1902725 negative regulation of satellite cell differentiation ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032433 filopodium tip IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008046 axon guidance receptor activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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