ENSG00000182580


Homo sapiens

Features
Gene ID: ENSG00000182580
  
Biological name :EPHB3
  
Synonyms : EPHB3 / EPH receptor B3 / P54753
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q27.1
Gene start: 184561784
Gene end: 184582409
  
Corresponding Affymetrix probe sets: 1438_at (Human Genome U133 Plus 2.0 Array)   204600_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000332118
NCBI entrez gene - 2049     See in Manteia.
OMIM - 601839
RefSeq - NM_004443
RefSeq Peptide - NP_004434
swissprot - P54753
Ensembl - ENSG00000182580
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ephb3aENSDARG00000031548Danio rerio
 EPHB3ENSGALG00000008537Gallus gallus
 Ephb3ENSMUSG00000005958Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHB1 / P54762 / EPH receptor B1ENSG0000015492869
EPHB2 / P29323 / EPH receptor B2ENSG0000013321669
EPHB4 / P54760 / EPH receptor B4ENSG0000019641158
EPHA4 / P54764 / EPH receptor A4ENSG0000011610656
EPHA3 / P29320 / EPH receptor A3ENSG0000004452455
EPHA5 / P54756 / EPH receptor A5ENSG0000014524255
EPHA7 / Q15375 / EPH receptor A7ENSG0000013533355
EPHA6 / Q9UF33 / EPH receptor A6ENSG0000008022454
EPHA8 / P29322 / EPH receptor A8ENSG0000007088650
EPHB6 / EPH receptor B6ENSG0000010612347
EPHA1 / P21709 / EPH receptor A1ENSG0000014690442


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034245  Ephrin type-B receptor 3, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis ISS
 biological_processGO:0001655 urogenital system development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007413 axonal fasciculation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IEA
 biological_processGO:0022038 corpus callosum development IEA
 biological_processGO:0022407 regulation of cell-cell adhesion IDA
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IDA
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048546 digestive tract morphogenesis IEA
 biological_processGO:0050770 regulation of axonogenesis IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060996 dendritic spine development IEA
 biological_processGO:0060997 dendritic spine morphogenesis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008046 axon guidance receptor activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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