ENSG00000135333


Homo sapiens

Features
Gene ID: ENSG00000135333
  
Biological name :EPHA7
  
Synonyms : EPHA7 / EPH receptor A7 / Q15375
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q16.1
Gene start: 93240020
Gene end: 93419547
  
Corresponding Affymetrix probe sets: 1554629_at (Human Genome U133 Plus 2.0 Array)   206852_at (Human Genome U133 Plus 2.0 Array)   229288_at (Human Genome U133 Plus 2.0 Array)   238533_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358303
Ensembl peptide - ENSP00000358309
NCBI entrez gene - 2045     See in Manteia.
OMIM - 602190
RefSeq - XM_017010365
RefSeq - NM_001288629
RefSeq - NM_001288630
RefSeq - NM_004440
RefSeq - XM_005248669
RefSeq Peptide - NP_004431
RefSeq Peptide - NP_001275558
RefSeq Peptide - NP_001275559
swissprot - Q15375
Ensembl - ENSG00000135333
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epha7ENSDARG00000004635Danio rerio
 EPHA7ENSGALG00000015593Gallus gallus
 Epha7ENSMUSG00000028289Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHA5 / P54756 / EPH receptor A5ENSG0000014524263
EPHA4 / P54764 / EPH receptor A4ENSG0000011610662
EPHA3 / P29320 / EPH receptor A3ENSG0000004452462
EPHA6 / Q9UF33 / EPH receptor A6ENSG0000008022459
EPHA8 / P29322 / EPH receptor A8ENSG0000007088657
EPHB2 / P29323 / EPH receptor B2ENSG0000013321657
EPHB1 / P54762 / EPH receptor B1ENSG0000015492856
EPHB3 / P54753 / EPH receptor B3ENSG0000018258055
EPHB4 / P54760 / EPH receptor B4ENSG0000019641148
EPHA1 / P21709 / EPH receptor A1ENSG0000014690444
EPHB6 / EPH receptor B6ENSG0000010612342


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034283  Ephrin type-A receptor 7, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development ISS
 biological_processGO:0016310 phosphorylation ISS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0022407 regulation of cell-cell adhesion ISS
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0031952 regulation of protein autophosphorylation ISS
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISS
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0048671 negative regulation of collateral sprouting IEA
 biological_processGO:0048755 branching morphogenesis of a nerve ISS
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050919 negative chemotaxis ISS
 biological_processGO:0051964 negative regulation of synapse assembly IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0072178 nephric duct morphogenesis IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISS
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008046 axon guidance receptor activity ISS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0045499 chemorepellent activity ISS
 molecular_functionGO:0046875 ephrin receptor binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr