ENSG00000133216


Homo sapiens

Features
Gene ID: ENSG00000133216
  
Biological name :EPHB2
  
Synonyms : EPHB2 / EPH receptor B2 / P29323
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.12
Gene start: 22710839
Gene end: 22921500
  
Corresponding Affymetrix probe sets: 209588_at (Human Genome U133 Plus 2.0 Array)   209589_s_at (Human Genome U133 Plus 2.0 Array)   210651_s_at (Human Genome U133 Plus 2.0 Array)   211165_x_at (Human Genome U133 Plus 2.0 Array)   230088_at (Human Genome U133 Plus 2.0 Array)   230119_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363758
Ensembl peptide - ENSP00000363763
Ensembl peptide - ENSP00000383053
Ensembl peptide - ENSP00000444174
Ensembl peptide - ENSP00000363761
NCBI entrez gene - 2048     See in Manteia.
OMIM - 600997
RefSeq - XM_006710442
RefSeq - NM_001309192
RefSeq - NM_001309193
RefSeq - NM_004442
RefSeq - NM_017449
RefSeq - XM_006710441
RefSeq Peptide - NP_004433
RefSeq Peptide - NP_059145
RefSeq Peptide - NP_001296121
RefSeq Peptide - NP_001296122
swissprot - P29323
swissprot - Q6NVW1
swissprot - B1AKC9
Ensembl - ENSG00000133216
  
Related genetic diseases (OMIM): 603688 - {Prostate cancer/brain cancer susceptibility, somatic}, 603688
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ephb2aENSDARG00000037373Danio rerio
 ephb2bENSDARG00000021539Danio rerio
 EPHB2ENSGALG00000004741Gallus gallus
 Ephb2ENSMUSG00000028664Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHB1 / P54762 / EPH receptor B1ENSG0000015492868
EPHB3 / P54753 / EPH receptor B3ENSG0000018258065
EPHA4 / P54764 / EPH receptor A4ENSG0000011610654
EPHA7 / Q15375 / EPH receptor A7ENSG0000013533354
EPHA5 / P54756 / EPH receptor A5ENSG0000014524253
EPHA3 / P29320 / EPH receptor A3ENSG0000004452452
EPHB4 / P54760 / EPH receptor B4ENSG0000019641152
EPHA6 / Q9UF33 / EPH receptor A6ENSG0000008022450
EPHA8 / P29322 / EPH receptor A8ENSG0000007088647
EPHB6 / EPH receptor B6ENSG0000010612344
EPHA1 / P21709 / EPH receptor A1ENSG0000014690439


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034238  Ephrin type-B receptor 2, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001525 angiogenesis ISS
 biological_processGO:0001655 urogenital system development ISS
 biological_processGO:0001933 negative regulation of protein phosphorylation ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007411 axon guidance ISS
 biological_processGO:0007413 axonal fasciculation ISS
 biological_processGO:0007611 learning or memory ISS
 biological_processGO:0007612 learning ISS
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021631 optic nerve morphogenesis IEA
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IEA
 biological_processGO:0022038 corpus callosum development ISS
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0031915 positive regulation of synaptic plasticity ISS
 biological_processGO:0042472 inner ear morphogenesis ISS
 biological_processGO:0046580 negative regulation of Ras protein signal transduction ISS
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity ISS
 biological_processGO:0048170 positive regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0050770 regulation of axonogenesis IEA
 biological_processGO:0050771 negative regulation of axonogenesis IEA
 biological_processGO:0050878 regulation of body fluid levels ISS
 biological_processGO:0051389 inactivation of MAPKK activity ISS
 biological_processGO:0051965 positive regulation of synapse assembly ISS
 biological_processGO:0060021 roof of mouth development ISS
 biological_processGO:0060996 dendritic spine development ISS
 biological_processGO:0060997 dendritic spine morphogenesis ISS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0071679 commissural neuron axon guidance ISS
 biological_processGO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission IEA
 biological_processGO:0106028 neuron projection retraction IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation ISS
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane ISS
 biological_processGO:1904782 negative regulation of NMDA glutamate receptor activity ISS
 biological_processGO:1904783 positive regulation of NMDA glutamate receptor activity ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0098794 postsynapse TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001540 amyloid-beta binding ISS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008046 axon guidance receptor activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding ISS


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
L1CAM interactions
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / complex / reaction






 

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