ENSG00000196411


Homo sapiens

Features
Gene ID: ENSG00000196411
  
Biological name :EPHB4
  
Synonyms : EPHB4 / EPH receptor B4 / P54760
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q22.1
Gene start: 100802565
Gene end: 100827521
  
Corresponding Affymetrix probe sets: 202894_at (Human Genome U133 Plus 2.0 Array)   216680_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000350896
Ensembl peptide - ENSP00000353833
Ensembl peptide - ENSP00000482702
NCBI entrez gene - 2050     See in Manteia.
OMIM - 600011
RefSeq - XM_017011816
RefSeq - NM_004444
RefSeq Peptide - NP_004435
swissprot - P54760
swissprot - Q541P7
swissprot - Q96L35
Ensembl - ENSG00000196411
  
Related genetic diseases (OMIM): 617300 - {Hydrops fetalis, nonimmune, and/or atrial septal defect}, 617300
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ephb4aENSDARG00000100725Danio rerio
 ephb4bENSDARG00000027112Danio rerio
 Ephb4ENSMUSG00000029710Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHB3 / P54753 / EPH receptor B3ENSG0000018258058
EPHB1 / P54762 / EPH receptor B1ENSG0000015492856
EPHB2 / P29323 / EPH receptor B2ENSG0000013321655
EPHA4 / P54764 / EPH receptor A4ENSG0000011610650
EPHA5 / P54756 / EPH receptor A5ENSG0000014524249
EPHA7 / Q15375 / EPH receptor A7ENSG0000013533349
EPHA6 / Q9UF33 / EPH receptor A6ENSG0000008022448
EPHA3 / P29320 / EPH receptor A3ENSG0000004452448
EPHA8 / P29322 / EPH receptor A8ENSG0000007088646
EPHB6 / EPH receptor B6ENSG0000010612343
EPHA1 / P21709 / EPH receptor A1ENSG0000014690441


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034290  Ephrin type-B receptor 4, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis ISS
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IDA
 biological_processGO:0003007 heart morphogenesis ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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