ENSDARG00000100725


Danio rerio

Features
Gene ID: ENSDARG00000100725
  
Biological name :ephb4a
  
Synonyms : ephb4a / eph receptor B4a
  
Possible biological names infered from orthology : EPHB4 / EPH receptor B4 / Ephrin type-B receptor 4 / P54760 / P54761
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 68408346
Gene end: 68495967
  
Corresponding Affymetrix probe sets: Dr.22293.1.A1_at (Zebrafish Array)   Dr.23044.1.A1_at (Zebrafish Array)   Dr.5764.1.S1_at (Zebrafish Array)   NM_131414_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000135357
Ensembl peptide - ENSDARP00000152897
Ensembl peptide - ENSDARP00000151029
Ensembl peptide - ENSDARP00000138034
NCBI entrez gene - 30688     See in Manteia.
RefSeq - NM_131414
RefSeq Peptide - NP_571489
swissprot - A4FUN2
swissprot - A0A0R4INV2
swissprot - A0A0R4IJK3
ZFIN ID - ZDB-GENE-990415-62
Ensembl - ENSDARG00000100725
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EPHB4ENSG00000196411Homo sapiens
 Ephb4ENSMUSG00000029710Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ephb4b / eph receptor B4b / EPHB4* / P54760* / P54761* / EPH receptor B4* / Ephrin type-B receptor 4 *ENSDARG0000002711270
ephb2b / eph receptor B2b / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *ENSDARG0000002153954
ephb2a / eph receptor B2a / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *ENSDARG0000003737354
ephb3a / eph receptor B3a / EPHB3* / P54753* / P54754* / EPH receptor B3* / Ephrin type-B receptor 3 *ENSDARG0000003154852
epha4b / eph receptor A4bENSDARG0000001160048
epha4l / eph receptor A4, like / EPHA4* / P54764* / Q03137* / EPH receptor A4* / Ephrin type-A receptor 4 *ENSDARG0000001076747
epha7 / eph receptor A7 / Q15375* / Q61772* / Ephrin type-A receptor 7 *ENSDARG0000000463547
ek1 / eph-like kinase 1ENSDARG0000002008047
CT990561.1 / EPHA5* / P54756* / EPH receptor A5*ENSDARG0000005828447
epha6 / eph receptor A6 / Q9UF33*ENSDARG0000002297146
epha3 / eph receptor A3 / P29320*ENSDARG0000003937345
epha2a / eph receptor A2 a / Epha2* / Q03145* / Ephrin type-A receptor 2 *ENSDARG0000001735444
ephb6 / eph receptor B6 / O08644* / Ephrin type-B receptor 6 *ENSDARG0000005772943
epha2b / eph receptor A2 bENSDARG0000002272742
ephb1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *ENSDARG0000007675741


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034290  Ephrin type-B receptor 4, ligand binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035475 angioblast cell migration involved in selective angioblast sprouting IMP
 biological_processGO:0048013 ephrin receptor signaling pathway IGI
 biological_processGO:0060026 convergent extension IGI
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta aplastic , abnormal
Show

 ZFA:0000107 eye eye fused with eye , abnormal
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 ZFA:0000135 notochord notochord decreased length , abnormal
notochord bent , abnormal
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 ZFA:0000155 somite somite condensed , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein increased amount , abnormal
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 ZFA:0001061 intersegmental artery intersegmental artery decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
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 ZFA:0001117 post-vent region post-vent region blood circulation absent , abnormal
post-vent region decreased length , abnormal
post-vent region bent , abnormal
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 ZFA:0001286 caudal vein plexus caudal vein plexus increased size , abnormal
caudal vein plexus malformed , abnormal
Show

 ZFA:0005037 post-vent vasculature post-vent vasculature malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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