ENSG00000145242


Homo sapiens

Features
Gene ID: ENSG00000145242
  
Biological name :EPHA5
  
Synonyms : EPHA5 / EPH receptor A5 / P54756
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q13.2
Gene start: 65319563
Gene end: 65670495
  
Corresponding Affymetrix probe sets: 215664_s_at (Human Genome U133 Plus 2.0 Array)   216837_at (Human Genome U133 Plus 2.0 Array)   237939_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427638
Ensembl peptide - ENSP00000389208
Ensembl peptide - ENSP00000478537
Ensembl peptide - ENSP00000480763
Ensembl peptide - ENSP00000273854
Ensembl peptide - ENSP00000346899
NCBI entrez gene - 2044     See in Manteia.
OMIM - 600004
RefSeq - XM_017007881
RefSeq - NM_001281765
RefSeq - NM_001281766
RefSeq - NM_001281767
RefSeq - NM_001318761
RefSeq - NM_004439
RefSeq - NM_182472
RefSeq - XM_005265653
RefSeq - XM_011531735
RefSeq - XM_017007878
RefSeq - XM_017007879
RefSeq - XM_017007880
RefSeq Peptide - NP_001268695
RefSeq Peptide - NP_001268696
RefSeq Peptide - NP_001305690
RefSeq Peptide - NP_004430
RefSeq Peptide - NP_872272
RefSeq Peptide - NP_001268694
swissprot - F8VP57
swissprot - F8W9W0
swissprot - B7ZKW7
swissprot - P54756
swissprot - B7ZKJ3
Ensembl - ENSG00000145242
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CT990561.1ENSDARG00000058284Danio rerio
 EPHA5ENSGALG00000011680Gallus gallus
 Epha5ENSMUSG00000029245Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHA3 / P29320 / EPH receptor A3ENSG0000004452464
EPHA4 / P54764 / EPH receptor A4ENSG0000011610662
EPHA7 / Q15375 / EPH receptor A7ENSG0000013533361
EPHA6 / Q9UF33 / EPH receptor A6ENSG0000008022459
EPHA8 / P29322 / EPH receptor A8ENSG0000007088656
EPHB1 / P54762 / EPH receptor B1ENSG0000015492854
EPHB2 / P29323 / EPH receptor B2ENSG0000013321654
EPHB3 / P54753 / EPH receptor B3ENSG0000018258053
EPHB4 / P54760 / EPH receptor B4ENSG0000019641146
EPHA1 / P21709 / EPH receptor A1ENSG0000014690441
EPHB6 / EPH receptor B6ENSG0000010612339


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034277  Ephrin type-A receptor 5, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019933 cAMP-mediated signaling ISS
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0032793 positive regulation of CREB transcription factor activity ISS
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048666 neuron development IEP
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:1904322 cellular response to forskolin IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IEA
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity NAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr