ENSG00000044524


Homo sapiens

Features
Gene ID: ENSG00000044524
  
Biological name :EPHA3
  
Synonyms : EPHA3 / EPH receptor A3 / P29320
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p11.1
Gene start: 89107524
Gene end: 89482134
  
Corresponding Affymetrix probe sets: 206070_s_at (Human Genome U133 Plus 2.0 Array)   206071_s_at (Human Genome U133 Plus 2.0 Array)   211164_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399926
Ensembl peptide - ENSP00000419190
Ensembl peptide - ENSP00000337451
NCBI entrez gene - 2042     See in Manteia.
OMIM - 179611
RefSeq - XM_005264716
RefSeq - NM_005233
RefSeq - NM_182644
RefSeq - XM_005264715
RefSeq Peptide - NP_005224
RefSeq Peptide - NP_872585
swissprot - C9JXA2
swissprot - P29320
swissprot - A0A140VJJ0
Ensembl - ENSG00000044524
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epha3ENSDARG00000039373Danio rerio
 EPHA3ENSGALG00000015403Gallus gallus
 Epha3ENSMUSG00000052504Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHA5 / P54756 / EPH receptor A5ENSG0000014524268
EPHA6 / Q9UF33 / EPH receptor A6ENSG0000008022464
EPHA4 / P54764 / EPH receptor A4ENSG0000011610663
EPHA7 / Q15375 / EPH receptor A7ENSG0000013533362
EPHA8 / P29322 / EPH receptor A8ENSG0000007088657
EPHB3 / P54753 / EPH receptor B3ENSG0000018258056
EPHB2 / P29323 / EPH receptor B2ENSG0000013321656
EPHB1 / P54762 / EPH receptor B1ENSG0000015492855
EPHB4 / P54760 / EPH receptor B4ENSG0000019641148
EPHA1 / P21709 / EPH receptor A1ENSG0000014690443
EPHB6 / EPH receptor B6ENSG0000010612341


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034266  Ephrin type-A receptor 3, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition ISS
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IDA
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0045806 negative regulation of endocytosis IDA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0051893 regulation of focal adhesion assembly IDA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IDA
 biological_processGO:0071300 cellular response to retinoic acid IMP
 biological_processGO:0097155 fasciculation of sensory neuron axon ISS
 biological_processGO:0097156 fasciculation of motor neuron axon ISS
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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