2042


Homo sapiens (NCBI)
regulationkinaseactivityreceptorproteinneuroncellplasmamembranebindingadhesiondevelopmentprojectioncytoskeletonorganizationcascadeephrinsignalingerkfasciculationaxontyrosinetransmembranemulticellularorganismsignaltransductionepithelialmesenchymaltransition

Features
Gene ID: 2042
  
Biological name :
  
Synonyms : EK4|ETK|ETK1|HEK|HEK4|TYRO4 / EPHA3 / EPH receptor A3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 206070_s_at (Human Genome U133 Plus 2.0 Array)   206071_s_at (Human Genome U133 Plus 2.0 Array)   211164_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 21361241
RefSeq - 32967314
RefSeq - 530373625
RefSeq - 530373627
RefSeq - NC_000003.12
RefSeq - NG_023239.1
RefSeq - NP_005224.2
RefSeq - NP_872585.1
RefSeq - XP_005264772.1
RefSeq - XP_005264773.1
RefSeq - NM_005233.5
RefSeq - NM_182644.2
RefSeq - XM_005264715.3
RefSeq - XM_005264716.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000044524 to get all the annotations available for this gene.


Gene Ontology (GO)
cell adhesionanatomical structure developmentcell communicationcellular response to stimuluscellular developmental processcellular component organizationlocalization of cellmovement of cell or subcellular componentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processactin filament-based processregulation of molecular functioncell deathestablishment of localizationcellular component biogenesismicrotubule-based processresponse to chemicalcell recognitionmacromolecule localizationcellular localizationcell adhesionanatomical structure developmentcell communicationcellular response to stimuluscellular developmental processcellular component organizationlocalization of cellmovement of cell or subcellular componentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processactin filament-based processregulation of molecular functioncell deathestablishment of localizationcellular component biogenesismicrotubule-based processresponse to chemicalcell recognitionmacromolecule localizationcellular localizationcell adhesionanatomical structure developmentcell communicationcellular response to stimuluscellular developmental processcellular component organizationlocalization of cellmovement of cell or subcellular componentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processactin filament-based processregulation of molecular functioncell deathestablishment of localizationcellular component biogenesismicrotubule-based processresponse to chemicalcell recognitionmacromolecule localizationcellular localizationcell adhesionanatomical structure developmentcell communicationcellular response to stimuluscellular developmental processcellular component organizationlocalization of cellmovement of cell or subcellular componentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processactin filament-based processregulation of molecular functioncell deathestablishment of localizationcellular component biogenesismicrotubule-based processresponse to chemicalcell recognitionmacromolecule localizationcellular localizationcell adhesionanatomical structure developmentcell communicationcellular response to stimuluscellular developmental processcellular component organizationlocalization of cellmovement of cell or subcellular componentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processactin filament-based processregulation of molecular functioncell deathestablishment of localizationcellular component biogenesismicrotubule-based processresponse to chemicalcell recognitionmacromolecule localizationcellular localizationcell adhesionanatomical structure developmentcell communicationcellular response to stimuluscellular developmental processcellular component organizationlocalization of cellmovement of cell or subcellular componentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processactin filament-based processregulation of molecular functioncell deathestablishment of localizationcellular component biogenesismicrotubule-based processresponse to chemicalcell recognitionmacromolecule localizationcellular localizationcell adhesionanatomical structure developmentcell communicationcellular response to stimuluscellular developmental processcellular component organizationlocalization of cellmovement of cell or subcellular componentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processactin filament-based processregulation of molecular functioncell deathestablishment of localizationcellular component biogenesismicrotubule-based processresponse to chemicalcell recognitionmacromolecule localizationcellular localizationcell adhesionanatomical structure developmentcell communicationcellular response to stimuluscellular developmental processcellular component organizationlocalization of cellmovement of cell or subcellular componentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processactin filament-based processregulation of molecular functioncell deathestablishment of localizationcellular component biogenesismicrotubule-based processresponse to chemicalcell recognitionmacromolecule localizationcellular localizationcell adhesionanatomical structure developmentcell communicationcellular response to stimuluscellular developmental processcellular component organizationlocalization of cellmovement of cell or subcellular componentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processactin filament-based processregulation of molecular functioncell deathestablishment of localizationcellular component biogenesismicrotubule-based processresponse to chemicalcell recognitionmacromolecule localizationcellular localizationcell adhesionanatomical structure developmentcell communicationcellular response to stimuluscellular developmental processcellular component organizationlocalization of cellmovement of cell or subcellular componentnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processactin filament-based processregulation of molecular functioncell deathestablishment of localizationcellular component biogenesismicrotubule-based processresponse to chemicalcell recognitionmacromolecule localizationcellular localizationcell acell adhesionanatomanatomical structure developmentcell ccell communicationcellulcellular response to stimuluscellulcellular developmental processcellulcellular component organizationlocalilocalization of cellmovememovement of cell or subcellular componentnitrognitrogen compound metabolic processcellulcellular metabolic processprimarprimary metabolic processorganiorganic substance metabolic processactin actin filament-based processregularegulation of molecular functioncell dcell deathestablestablishment of localizationcellulcellular component biogenesismicrotmicrotubule-based processresponresponse to chemicalcell rcell recognitionmacrommacromolecule localizationcellulcellular localization
catalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic activity, acting on a proteintransferase activitysignaling receptor activityprotein bindingion bindingcarbohydrate derivative bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingdrug bindingcatalytic acticatalytic activity, acting on a proteintransferase actransferase activitysignaling recesignaling receptor activityprotein bindinprotein bindingion bindingion bindingcarbohydrate dcarbohydrate derivative bindingorganic cyclicorganic cyclic compound bindingheterocyclic cheterocyclic compound bindingsmall moleculesmall molecule bindingdrug bindingdrug binding
extracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regioncellorganellemembraneprotein-containing complexextracellular regionextracellular regioncellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition ISS
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IDA
 biological_processGO:0033674 positive regulation of kinase activity IBA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IBA
 biological_processGO:0045806 negative regulation of endocytosis IDA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0051893 regulation of focal adhesion assembly IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IDA
 biological_processGO:0071300 cellular response to retinoic acid IMP
 biological_processGO:0097155 fasciculation of sensory neuron axon ISS
 biological_processGO:0097156 fasciculation of motor neuron axon ISS
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0043235 receptor complex IBA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0004713 protein tyrosine kinase activity IBA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IBA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IDA
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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