ENSGALG00000006609


Gallus gallus

Features
Gene ID: ENSGALG00000006609
  
Biological name :EPHB1
  
Synonyms : EPHB1 / EPH receptor B1
  
Possible biological names infered from orthology : Ephrin type-B receptor 1 / P54762 / Q8CBF3
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 3708138
Gene end: 3751383
  
Corresponding Affymetrix probe sets: Gga.694.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000010654
NCBI entrez gene - 396177     See in Manteia.
RefSeq - XM_015277145
RefSeq - XM_015277146
swissprot - F1P4I4
Ensembl - ENSGALG00000006609
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ephb1ENSDARG00000076757Danio rerio
 EPHB1ENSG00000154928Homo sapiens
 Ephb1ENSMUSG00000032537Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *ENSGALG0000000474172
EPHB3 / EPH receptor B3 / P54753* / P54754* / Ephrin type-B receptor 3 *ENSGALG0000000853769
EPHB6 / ephrin type-B receptor 5 precursor / O08644* / EPH receptor B6* / Ephrin type-B receptor 6 *ENSGALG0000001474959
EPHA4 / ephrin type-A receptor 4 precursor / Q03137* / P54764* / EPH receptor A4* / Ephrin type-A receptor 4 *ENSGALG0000000525658
EPHA7 / O42422 / Ephrin type-A receptor 7 / Q15375* / Q61772* / EPH receptor A7*ENSGALG0000001559356
EPHA5 / ephrin type-A receptor 5 precursor / Q60629* / P54756* / EPH receptor A5* / Ephrin type-A receptor 5 *ENSGALG0000001168056
EPHA3 / ephrin type-A receptor 3 precursor / P29320* / EPH receptor A3*ENSGALG0000001540355
EPHA8 / EPH receptor A8 / O09127* / P29322* / Ephrin type-A receptor 8 *ENSGALG0000002156752
EPHA6 / EPH receptor A6 / Q9UF33*ENSGALG0000001541839


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0014719 skeletal muscle satellite cell activation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021545 cranial nerve development IEA
 biological_processGO:0021631 optic nerve morphogenesis IEA
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IEA
 biological_processGO:0022008 neurogenesis IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0060996 dendritic spine development IEA
 biological_processGO:0060997 dendritic spine morphogenesis IEA
 biological_processGO:0061351 neural precursor cell proliferation IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1901214 regulation of neuron death IEA
 biological_processGO:1902723 negative regulation of skeletal muscle satellite cell proliferation IEA
 biological_processGO:1902725 negative regulation of satellite cell differentiation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032433 filopodium tip IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008046 axon guidance receptor activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / complex / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction / complex
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / - / reaction / complex
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex
 ENSGALG00000008898 GRIN1 / glutamate ionotropic receptor NMDA type subunit 1 / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 *  / complex
 ENSGALG00000014923 ARHGEF28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*  / reaction / complex
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / - / reaction / complex
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / - / reaction / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000042321 LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / complex
 ENSGALG00000017706 RASA1* / P20936* / RAS p21 protein activator 1*  / complex
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / complex
 ENSGALG00000014860 YES1 / P09324 / Tyrosine-protein kinase Yes / Q04736* / P07947* / YES proto-oncogene 1, Src family tyrosine kinase*  / complex
 ENSGALG00000015436 SDCBP / syndecan binding protein / O00560* / O08992*  / reaction / complex
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSGALG00000000280 EFNA5 / ephrin-A5 precursor / O08543* / P52803* / ephrin A5*  / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / complex / reaction
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000009621 ACTB / P60706 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / P60709* / P60710* / actin beta*  / complex / reaction
 ENSGALG00000015842 TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*  / reaction / complex
 ENSGALG00000023703 GIT1 / GIT ArfGAP 1 / Q68FF6* / Q9Y2X7* / ARF GTPase-activating protein GIT1 *  / reaction / complex






 

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