ENSGALG00000008058


Gallus gallus

Features
Gene ID: ENSGALG00000008058
  
Biological name :PAK3
  
Synonyms : p21 (RAC1) activated kinase 3 / PAK3
  
Possible biological names infered from orthology : O75914 / Q61036 / Serine/threonine-protein kinase PAK 3
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 13443252
Gene end: 13504827
  
Corresponding Affymetrix probe sets: GgaAffx.5048.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013062
NCBI entrez gene - 422342     See in Manteia.
RefSeq - XM_015278598
RefSeq - XM_015278599
swissprot - F1N8W8
Ensembl - ENSGALG00000008058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PAK3ENSG00000077264Homo sapiens
 Pak3ENSMUSG00000031284Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*ENSGALG0000000068181
PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*ENSGALG0000000642674
PAK5 / p21 (RAC1) activated kinase 5 / Pak7* / Q8C015* / Q9P286* / Serine/threonine-protein kinase PAK 5 *ENSGALG0000000894737
PAK6* / Q9NQU5* / Q3ULB5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6* / Serine/threonine-protein kinase PAK 6 *ENSGALG0000003460535
PAK4 / p21 (RAC1) activated kinase 4 / O96013* / Q8BTW9* / Serine/threonine-protein kinase PAK 4 *ENSGALG0000003132834
TAOK1 / TAO kinase 1 / Q5F2E8* / Q7L7X3*ENSGALG0000000408224
TAOK3 / serine/threonine-protein kinase TAO3 / Q8BYC6* / Q9H2K8* / TAO kinase 3*ENSGALG0000000739622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016358 dendrite development IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0050770 regulation of axonogenesis IBA
 biological_processGO:0060996 dendritic spine development IEA
 biological_processGO:0060997 dendritic spine morphogenesis IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004708 MAP kinase kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000001264 PLXNA2 / plexin A2 / O75051* / P70207*  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / reaction / complex
 ENSGALG00000008340 FES / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *  / complex / reaction
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / reaction / complex
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex / reaction
 ENSGALG00000032349 CDH5 / Q8AYD0 / Cadherin-5 / P33151* / P55284*  / reaction
 ENSGALG00000001076 LIMK1 / Q8QFP8 / LIM domain kinase 1 / P53667* / P53668*  / reaction
 ENSGALG00000017414 JUP / junction plakoglobin / P14923* / Q02257*  / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / reaction / complex
 ENSGALG00000023703 GIT1 / GIT ArfGAP 1 / Q68FF6* / Q9Y2X7* / ARF GTPase-activating protein GIT1 *  / complex / reaction
 ENSGALG00000006097 PLXNA1 / plexin A1 / P70206* / Q9UIW2*  / reaction / complex
 ENSGALG00000002447 CTNNA1 / catenin alpha 1 / P26231* / P35221*  / reaction
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex / reaction
 ENSGALG00000031448 MAPK6 / Q5F3W3 / Mitogen-activated protein kinase 6 / Q16659* / Q61532*  / reaction
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr