ENSGALG00000004998


Gallus gallus

Features
Gene ID: ENSGALG00000004998
  
Biological name :RAF1
  
Synonyms : P05625 / RAF1 / RAF proto-oncogene serine/threonine-protein kinase
  
Possible biological names infered from orthology : Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049 / Q99N57 / Raf-1 proto-oncogene, serine/threonine kinase
  
Species: Gallus gallus
  
Chr. number: 12
Strand: -1
Band:
Gene start: 4945518
Gene end: 4973456
  
Corresponding Affymetrix probe sets: Gga.685.1.S1_at (Chicken Array)   Gga.685.1.S2_at (Chicken Array)   Gga.685.3.A1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000051230
Ensembl peptide - ENSGALP00000033314
Ensembl peptide - ENSGALP00000046736
NCBI entrez gene - 396245     See in Manteia.
RefSeq - XM_015293014
RefSeq - NM_205307
RefSeq - XM_015293011
RefSeq - XM_015293012
RefSeq - XM_015293013
RefSeq - XM_015293009
RefSeq - XM_015293010
RefSeq Peptide - NP_990638
swissprot - P05625
swissprot - A0A1D5PEM5
Ensembl - ENSGALG00000004998
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 raf1aENSDARG00000102328Danio rerio
 raf1aENSDARG00000096415Danio rerio
 raf1bENSDARG00000059406Danio rerio
 RAF1ENSG00000132155Homo sapiens
 Raf1ENSMUSG00000000441Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*ENSGALG0000001286555
KSR2 / kinase suppressor of ras 2 / Q6VAB6*ENSGALG0000002090524
KSR1 / kinase suppressor of ras 1 / Q61097* / Q8IVT5* / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA.*ENSGALG0000000568521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003116  Raf-like Ras-binding
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001678 cellular glucose homeostasis IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007190 activation of adenylate cyclase activity IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035773 insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045104 intermediate filament cytoskeleton organization IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071550 death-inducing signaling complex assembly IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031143 pseudopodium IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Rap1 signalling
GP1b-IX-V activation signalling
CREB phosphorylation through the activation of Ras
CD209 (DC-SIGN) signaling
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / reaction
 ENSGALG00000007403 PEBP1 / phosphatidylethanolamine binding protein 1 / Pbp2* / P30086* / P70296*  / complex / reaction
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / complex / reaction
 ENSGALG00000013971 SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*  / complex
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction / complex
 ENSGALG00000029881 LAMTOR2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 / Q9JHS3* / Q9Y2Q5* / Ragulator complex protein LAMTOR2 *  / reaction / complex
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / complex
 ENSGALG00000012865 BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*  / reaction / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000009927 RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / reaction / complex
 ENSGALG00000000055 Q5ZIP2 / LAMTOR3 / Ragulator complex protein LAMTOR3 / O88653* / Q9UHA4* / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3*  / complex / reaction
 ENSGALG00000004143 YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / complex / reaction
 ENSGALG00000007687 MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *  / complex / reaction
 ENSGALG00000011505 MARK3 / microtubule affinity regulating kinase 3 / P27448* / Q03141* / MAP/microtubule affinity-regulating kinase 3 *  / reaction / complex
 ENSGALG00000043570 SGK3 / serum/glucocorticoid regulated kinase family member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*  / complex
 ENSGALG00000041795 WWP1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*  / complex
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / complex / reaction
 ENSGALG00000027069 TSC22D3 / TSC22 domain family member 3 / Q99576* / Q9Z2S7* / TSC22 domain family protein 3 *  / complex
 ENSGALG00000031387 YWHAZ / Q5ZKC9 / 14-3-3 protein zeta / P63104* / P63101* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...  / reaction / complex






 

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