ENSGALG00000005685


Gallus gallus

Features
Gene ID: ENSGALG00000005685
  
Biological name :KSR1
  
Synonyms : kinase suppressor of ras 1 / KSR1
  
Possible biological names infered from orthology : Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q61097 / Q8IVT5
  
Species: Gallus gallus
  
Chr. number: 19
Strand: 1
Band:
Gene start: 9192199
Gene end: 9230027
  
Corresponding Affymetrix probe sets: Gga.11110.1.A1_at (Chicken Array)   Gga.5633.1.S1_at (Chicken Array)   GgaAffx.26564.1.S1_at (Chicken Array)   GgaAffx.26564.1.S1_s_at (Chicken Array)   GgaAffx.26564.2.S1_at (Chicken Array)   GgaAffx.26564.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009104
Ensembl peptide - ENSGALP00000057977
Ensembl peptide - ENSGALP00000055392
Ensembl peptide - ENSGALP00000050736
Ensembl peptide - ENSGALP00000044404
NCBI entrez gene - 427839     See in Manteia.
RefSeq - XM_425413
RefSeq - XM_004946781
RefSeq - XM_004946782
RefSeq - XM_015295861
RefSeq - XM_015295862
RefSeq - XM_015295863
RefSeq - XM_004946780
swissprot - A0A1D5PYC6
swissprot - A0A1D5PR70
swissprot - A0A1D5PD92
swissprot - A0A1D5NVM9
swissprot - E1C7R3
Ensembl - ENSGALG00000005685
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ksr1aENSDARG00000068714Danio rerio
 ksr1bENSDARG00000030933Danio rerio
 KSR1ENSG00000141068Homo sapiens
 Ksr1ENSMUSG00000018334Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KSR2 / kinase suppressor of ras 2 / Q6VAB6*ENSGALG0000002090559
BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*ENSGALG0000001286526
RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...ENSGALG0000000499825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005078 MAP-kinase scaffold activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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