ENSG00000141068


Homo sapiens

Features
Gene ID: ENSG00000141068
  
Biological name :KSR1
  
Synonyms : kinase suppressor of ras 1 / KSR1 / Q8IVT5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q11.2
Gene start: 27456470
Gene end: 27626438
  
Corresponding Affymetrix probe sets: 213767_at (Human Genome U133 Plus 2.0 Array)   213769_at (Human Genome U133 Plus 2.0 Array)   213770_at (Human Genome U133 Plus 2.0 Array)   235252_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464680
Ensembl peptide - ENSP00000464081
Ensembl peptide - ENSP00000494039
Ensembl peptide - ENSP00000494552
Ensembl peptide - ENSP00000268763
Ensembl peptide - ENSP00000381952
Ensembl peptide - ENSP00000381958
Ensembl peptide - ENSP00000438795
Ensembl peptide - ENSP00000463554
Ensembl peptide - ENSP00000463790
NCBI entrez gene - 8844     See in Manteia.
OMIM - 601132
RefSeq - XM_017025278
RefSeq - XM_017025270
RefSeq - XM_017025271
RefSeq - XM_017025272
RefSeq - XM_017025273
RefSeq - XM_017025274
RefSeq - XM_017025275
RefSeq - XM_017025276
RefSeq - XM_017025277
RefSeq - NM_014238
RefSeq - XM_006722154
RefSeq - XM_011525429
RefSeq - XM_011525430
RefSeq - XM_011525431
RefSeq - XM_017025267
RefSeq - XM_017025268
RefSeq - XM_017025269
RefSeq Peptide - NP_055053
swissprot - J3QLI1
swissprot - J3QQL4
swissprot - J3QR75
swissprot - J3QSG8
swissprot - A0A0A0MQW1
swissprot - A8MY87
swissprot - Q8IVT5
Ensembl - ENSG00000141068
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ksr1aENSDARG00000068714Danio rerio
 ksr1bENSDARG00000030933Danio rerio
 KSR1ENSGALG00000005685Gallus gallus
 Ksr1ENSMUSG00000018334Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KSR2 / Q6VAB6 / kinase suppressor of ras 2ENSG0000017143553
BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinaseENSG0000015776421
ARAF / P10398 / A-Raf proto-oncogene, serine/threonine kinaseENSG0000007806121
RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinaseENSG0000013215521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR025561  Kinase suppressor of RAS, SAM-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0007265 Ras protein signal transduction IBA
 biological_processGO:0019933 cAMP-mediated signaling ISS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004672 protein kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005078 MAP-kinase scaffold activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IDA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction / complex
 ENSG00000075413 MARK3 / P27448 / microtubule affinity regulating kinase 3  / complex
 ENSG00000126934 MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2  / complex / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction / complex
 ENSG00000089234 BRAP / Q7Z569 / BRCA1 associated protein  / reaction / complex
 ENSG00000169032 MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / complex / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction / complex
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / complex / reaction
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / complex / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction / complex
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / reaction / complex






 

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