ENSG00000075413


Homo sapiens

Features
Gene ID: ENSG00000075413
  
Biological name :MARK3
  
Synonyms : MARK3 / microtubule affinity regulating kinase 3 / P27448
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.32
Gene start: 103385392
Gene end: 103503831
  
Corresponding Affymetrix probe sets: 202568_s_at (Human Genome U133 Plus 2.0 Array)   202569_s_at (Human Genome U133 Plus 2.0 Array)   232537_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450460
Ensembl peptide - ENSP00000411397
Ensembl peptide - ENSP00000450772
Ensembl peptide - ENSP00000454169
Ensembl peptide - ENSP00000452893
Ensembl peptide - ENSP00000452829
Ensembl peptide - ENSP00000451623
Ensembl peptide - ENSP00000216288
Ensembl peptide - ENSP00000303698
Ensembl peptide - ENSP00000335347
Ensembl peptide - ENSP00000402104
Ensembl peptide - ENSP00000408092
NCBI entrez gene - 4140     See in Manteia.
OMIM - 602678
RefSeq - XM_017021311
RefSeq - XM_017021295
RefSeq - XM_017021296
RefSeq - XM_017021297
RefSeq - XM_017021298
RefSeq - XM_017021299
RefSeq - XM_017021300
RefSeq - XM_017021301
RefSeq - XM_017021302
RefSeq - XM_017021303
RefSeq - XM_017021304
RefSeq - XM_017021305
RefSeq - XM_017021306
RefSeq - XM_017021307
RefSeq - XM_017021308
RefSeq - XM_017021309
RefSeq - XM_017021310
RefSeq - NM_001128918
RefSeq - NM_001128919
RefSeq - NM_001128920
RefSeq - NM_001128921
RefSeq - NM_002376
RefSeq - XM_005267641
RefSeq - XM_005267642
RefSeq - XM_005267643
RefSeq - XM_006720146
RefSeq - XM_011536769
RefSeq - XM_017021291
RefSeq - XM_017021292
RefSeq - XM_017021293
RefSeq - XM_017021294
RefSeq Peptide - NP_002367
RefSeq Peptide - NP_001122392
RefSeq Peptide - NP_001122393
RefSeq Peptide - NP_001122390
RefSeq Peptide - NP_001122391
swissprot - H0YKJ3
swissprot - H0YKP9
swissprot - H0YNV4
swissprot - A2SY06
swissprot - P27448
swissprot - A0A0A0MQR8
swissprot - J3KNR0
swissprot - A0A0A0MT23
swissprot - A0A0A0MSZ1
swissprot - A0A0A0MST9
swissprot - H0YIY6
Ensembl - ENSG00000075413
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mark3bENSDARG00000026630Danio rerio
 MARK3ENSGALG00000011505Gallus gallus
 Mark3ENSMUSG00000007411Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MARK1 / Q9P0L2 / microtubule affinity regulating kinase 1ENSG0000011614174
MARK2 / Q7KZI7 / microtubule affinity regulating kinase 2ENSG0000007251866
MARK4 / Q96L34 / microtubule affinity regulating kinase 4ENSG0000000704763
SIK3 / SIK family kinase 3ENSG0000016058435
SIK2 / Q9H0K1 / salt inducible kinase 2ENSG0000017014531
SIK1B / salt inducible kinase 1B (putative)ENSG0000027599330
SIK1 / P57059 / salt inducible kinase 1ENSG0000014217830
SNRK / Q9NRH2 / SNF related kinaseENSG0000016378829
NIM1K / Q8IY84 / NIM1 serine/threonine protein kinaseENSG0000017745320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR033628  Serine/threonine-protein kinase MARK3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0035331 negative regulation of hippo signaling IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / complex / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction / complex
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction / complex
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / reaction / complex
 ENSG00000089234 BRAP / Q7Z569 / BRCA1 associated protein  / reaction / complex
 ENSG00000141068 KSR1 / Q8IVT5 / kinase suppressor of ras 1  / complex
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction / complex
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / complex / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / complex / reaction
 ENSG00000169032 MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1  / complex / reaction
 ENSG00000126934 MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2  / complex / reaction






 

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