ENSG00000116141


Homo sapiens

Features
Gene ID: ENSG00000116141
  
Biological name :MARK1
  
Synonyms : MARK1 / microtubule affinity regulating kinase 1 / Q9P0L2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q41
Gene start: 220528183
Gene end: 220664461
  
Corresponding Affymetrix probe sets: 1560407_at (Human Genome U133 Plus 2.0 Array)   221047_s_at (Human Genome U133 Plus 2.0 Array)   226653_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386017
Ensembl peptide - ENSP00000483424
Ensembl peptide - ENSP00000355884
Ensembl peptide - ENSP00000355885
NCBI entrez gene - 4139     See in Manteia.
OMIM - 606511
RefSeq - XM_017001307
RefSeq - NM_018650
RefSeq - XM_005273134
RefSeq - XM_006711326
RefSeq - XM_011509561
RefSeq - XM_011509562
RefSeq - XM_017001305
RefSeq - XM_017001306
RefSeq - NM_001286124
RefSeq - NM_001286126
RefSeq - NM_001286128
RefSeq Peptide - NP_061120
RefSeq Peptide - NP_001273053
RefSeq Peptide - NP_001273055
RefSeq Peptide - NP_001273057
swissprot - Q9P0L2
swissprot - B4DIB3
swissprot - A0A087X0I6
Ensembl - ENSG00000116141
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mark3bENSDARG00000026630Danio rerio
 MARK1ENSGALG00000009483Gallus gallus
 Mark1ENSMUSG00000026620Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MARK3 / P27448 / microtubule affinity regulating kinase 3ENSG0000007541370
MARK2 / Q7KZI7 / microtubule affinity regulating kinase 2ENSG0000007251867
MARK4 / Q96L34 / microtubule affinity regulating kinase 4ENSG0000000704756
SIK3 / SIK family kinase 3ENSG0000016058433
SIK1 / P57059 / salt inducible kinase 1ENSG0000014217828
SIK1B / salt inducible kinase 1B (putative)ENSG0000027599328
SIK2 / Q9H0K1 / salt inducible kinase 2ENSG0000017014528
SNRK / Q9NRH2 / SNF related kinaseENSG0000016378827
NIM1K / Q8IY84 / NIM1 serine/threonine protein kinaseENSG0000017745319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR033627  Serine/threonine-protein kinase MARK1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015630 microtubule cytoskeleton TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity IEA
 molecular_functionGO:0070300 phosphatidic acid binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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