ENSG00000072518


Homo sapiens

Features
Gene ID: ENSG00000072518
  
Biological name :MARK2
  
Synonyms : MARK2 / microtubule affinity regulating kinase 2 / Q7KZI7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 63838928
Gene end: 63911019
  
Corresponding Affymetrix probe sets: 203942_s_at (Human Genome U133 Plus 2.0 Array)   211082_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423844
Ensembl peptide - ENSP00000423452
Ensembl peptide - ENSP00000423974
Ensembl peptide - ENSP00000444956
Ensembl peptide - ENSP00000444859
Ensembl peptide - ENSP00000437509
Ensembl peptide - ENSP00000425765
Ensembl peptide - ENSP00000294247
Ensembl peptide - ENSP00000355091
Ensembl peptide - ENSP00000367041
Ensembl peptide - ENSP00000385751
Ensembl peptide - ENSP00000386128
Ensembl peptide - ENSP00000415494
Ensembl peptide - ENSP00000421075
NCBI entrez gene - 2011     See in Manteia.
OMIM - 600526
RefSeq - XM_017017311
RefSeq - NM_001163297
RefSeq - NM_004954
RefSeq - NM_017490
RefSeq - XM_011544789
RefSeq - XM_011544790
RefSeq - XM_011544791
RefSeq - XM_011544792
RefSeq - XM_011544793
RefSeq - XM_011544794
RefSeq - XM_011544795
RefSeq - XM_011544796
RefSeq - XM_011544797
RefSeq - XM_011544798
RefSeq - XM_017017310
RefSeq - NM_001039469
RefSeq - NM_001163296
RefSeq Peptide - NP_001156768
RefSeq Peptide - NP_001156769
RefSeq Peptide - NP_004945
RefSeq Peptide - NP_059672
RefSeq Peptide - NP_001034558
swissprot - F5H4J8
swissprot - F5H6N2
swissprot - Q7KZI7
swissprot - A0A024R5B2
swissprot - E9PC69
swissprot - E7ETY4
swissprot - A0A1B0GXH6
swissprot - A0A140VJP1
swissprot - F5H4F6
Ensembl - ENSG00000072518
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mark2aENSDARG00000079905Danio rerio
 mark2bENSDARG00000032458Danio rerio
 Mark2ENSMUSG00000024969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MARK1 / Q9P0L2 / microtubule affinity regulating kinase 1ENSG0000011614167
MARK3 / P27448 / microtubule affinity regulating kinase 3ENSG0000007541363
MARK4 / Q96L34 / microtubule affinity regulating kinase 4ENSG0000000704753
SIK3 / SIK family kinase 3ENSG0000016058434
SIK2 / Q9H0K1 / salt inducible kinase 2ENSG0000017014529
SIK1 / P57059 / salt inducible kinase 1ENSG0000014217828
SIK1B / salt inducible kinase 1B (putative)ENSG0000027599328
SNRK / Q9NRH2 / SNF related kinaseENSG0000016378826
NIM1K / Q8IY84 / NIM1 serine/threonine protein kinaseENSG0000017745319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0000422 autophagy of mitochondrion NAS
 biological_processGO:0001764 neuron migration ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010976 positive regulation of neuron projection development IDA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation TAS
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032147 activation of protein kinase activity TAS
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IDA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0050770 regulation of axonogenesis IMP
 biological_processGO:0051493 regulation of cytoskeleton organization ISS
 biological_processGO:0051646 mitochondrion localization NAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion NAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IMP
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0097427 microtubule bundle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030295 protein kinase activator activity TAS
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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