ENSG00000170145


Homo sapiens

Features
Gene ID: ENSG00000170145
  
Biological name :SIK2
  
Synonyms : Q9H0K1 / salt inducible kinase 2 / SIK2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.1
Gene start: 111602391
Gene end: 111730853
  
Corresponding Affymetrix probe sets: 1556056_at (Human Genome U133 Plus 2.0 Array)   213221_s_at (Human Genome U133 Plus 2.0 Array)   215752_at (Human Genome U133 Plus 2.0 Array)   223430_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305976
NCBI entrez gene - 23235     See in Manteia.
OMIM - 608973
RefSeq - XM_017017418
RefSeq - NM_015191
RefSeq - XM_017017417
RefSeq Peptide - NP_056006
swissprot - Q9H0K1
swissprot - A0A024R3G7
Ensembl - ENSG00000170145
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sik2aENSDARG00000079618Danio rerio
 sik2bENSDARG00000062315Danio rerio
 SIK2ENSGALG00000036873Gallus gallus
 Sik2ENSMUSG00000037112Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIK1 / P57059 / salt inducible kinase 1ENSG0000014217841
SIK1B / salt inducible kinase 1B (putative)ENSG0000027599341
SIK3 / SIK family kinase 3ENSG0000016058437
MARK2 / Q7KZI7 / microtubule affinity regulating kinase 2ENSG0000007251825
MARK3 / P27448 / microtubule affinity regulating kinase 3ENSG0000007541325
MARK4 / Q96L34 / microtubule affinity regulating kinase 4ENSG0000000704725
MARK1 / Q9P0L2 / microtubule affinity regulating kinase 1ENSG0000011614124
SNRK / Q9NRH2 / SNF related kinaseENSG0000016378819
NIM1K / Q8IY84 / NIM1 serine/threonine protein kinaseENSG0000017745316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017090  Serine/threonine-protein kinase, SIK1/2
 IPR017441  Protein kinase, ATP binding site
 IPR034672  Salt-Inducible kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0046626 regulation of insulin receptor signaling pathway ISS
 biological_processGO:0046777 protein autophosphorylation IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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