ENSMUSG00000037112


Mus musculus

Features
Gene ID: ENSMUSG00000037112
  
Biological name :Sik2
  
Synonyms : salt inducible kinase 2 / Sik2
  
Possible biological names infered from orthology : Q9H0K1
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 50892801
Gene end: 51009073
  
Corresponding Affymetrix probe sets: 10593430 (MoGene1.0st)   1419871_at (Mouse Genome 430 2.0 Array)   1457276_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038761
Ensembl peptide - ENSMUSP00000134936
Ensembl peptide - ENSMUSP00000134954
Ensembl peptide - ENSMUSP00000135376
NCBI entrez gene - 235344     See in Manteia.
MGI - MGI:2445031
RefSeq - XM_017313332
RefSeq - NM_178710
RefSeq - XM_006510266
RefSeq - XM_006510267
RefSeq Peptide - NP_848825
swissprot - H3BKG1
swissprot - H3BJC9
swissprot - F8VPT7
Ensembl - ENSMUSG00000037112
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sik2aENSDARG00000079618Danio rerio
 sik2bENSDARG00000062315Danio rerio
 SIK2ENSGALG00000036873Gallus gallus
 SIK2ENSG00000170145Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sik1 / Q60670 / Serine/threonine-protein kinase SIK1 / SIK1B* / P57059* / salt inducible kinase 1* / salt inducible kinase 1B (putative)*ENSMUSG0000002404239
Sik3 / SIK family kinase 3ENSMUSG0000003413536
Mark4 / Q8CIP4 / MAP/microtubule affinity-regulating kinase 4 / Q96L34* / microtubule affinity regulating kinase 4*ENSMUSG0000003039725
Mark1 / Q8VHJ5 / Serine/threonine-protein kinase MARK1 / Q9P0L2* / microtubule affinity regulating kinase 1*ENSMUSG0000002662024
Mark2 / microtubule affinity regulating kinase 2 / Q7KZI7*ENSMUSG0000002496924
Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*ENSMUSG0000000741124
Snrk / Q8VDU5 / Mus musculus SNF related kinase (Snrk), transcript variant 5, mRNA. / Q9NRH2* / SNF related kinase*ENSMUSG0000003814518
Nim1k / Q8BHI9 / Serine/threonine-protein kinase NIM1 / Q8IY84* / NIM1 serine/threonine protein kinase*ENSMUSG0000009593015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017090  Serine/threonine-protein kinase, SIK1/2
 IPR017441  Protein kinase, ATP binding site
 IPR034672  Salt-Inducible kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ay/a,Sik2tm1Htake/Sik2+
Genetic Background: C57BL/6-Sik2tm1Htake

Allelic Composition: Sik2tm1Htake/Sik2tm1Htake
Genetic Background: C57BL/6-Sik2tm1Htake

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0014172 decreased fatty acid oxidation 
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0030017 decreased adipocyte glucose uptake "reduced ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
Show

Allelic Composition: Camta1tm1.1Eno/Camta1tm1.1Eno,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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