ENSMUSG00000024969


Mus musculus

Features
Gene ID: ENSMUSG00000024969
  
Biological name :Mark2
  
Synonyms : Mark2 / microtubule affinity regulating kinase 2
  
Possible biological names infered from orthology : Q7KZI7
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 7275396
Gene end: 7341860
  
Corresponding Affymetrix probe sets: 10465649 (MoGene1.0st)   10465651 (MoGene1.0st)   1415952_at (Mouse Genome 430 2.0 Array)   1415953_s_at (Mouse Genome 430 2.0 Array)   1435889_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128779
Ensembl peptide - ENSMUSP00000128560
Ensembl peptide - ENSMUSP00000129067
Ensembl peptide - ENSMUSP00000132482
Ensembl peptide - ENSMUSP00000131684
Ensembl peptide - ENSMUSP00000131266
Ensembl peptide - ENSMUSP00000129924
Ensembl peptide - ENSMUSP00000129894
Ensembl peptide - ENSMUSP00000129506
Ensembl peptide - ENSMUSP00000129490
Ensembl peptide - ENSMUSP00000025921
Ensembl peptide - ENSMUSP00000032557
Ensembl peptide - ENSMUSP00000108969
Ensembl peptide - ENSMUSP00000125944
Ensembl peptide - ENSMUSP00000126468
Ensembl peptide - ENSMUSP00000126753
Ensembl peptide - ENSMUSP00000127827
Ensembl peptide - ENSMUSP00000128549
NCBI entrez gene - 13728     See in Manteia.
MGI - MGI:99638
RefSeq - XM_017318059
RefSeq - NM_001080388
RefSeq - NM_001080389
RefSeq - NM_001080390
RefSeq - NM_007928
RefSeq - XM_006526641
RefSeq - XM_006526642
RefSeq - XM_006526643
RefSeq - XM_006526644
RefSeq - XM_006526645
RefSeq - XM_006526646
RefSeq - XM_006526647
RefSeq - XM_006526648
RefSeq - XM_006526650
RefSeq - XM_006526652
RefSeq - XM_006526654
RefSeq - XM_006526656
RefSeq - XM_011247139
RefSeq - XM_017318058
RefSeq Peptide - NP_001073857
RefSeq Peptide - NP_001073859
RefSeq Peptide - NP_031954
RefSeq Peptide - NP_001073858
swissprot - E9Q2J6
swissprot - E9Q2G8
swissprot - E9PZ55
swissprot - E9PYX3
swissprot - F6UY70
swissprot - F6Z4Q6
swissprot - F6ZEX4
swissprot - F6ZS70
swissprot - F7A3Q3
swissprot - F7CRG8
swissprot - F7CVZ7
swissprot - A0A0R4J227
swissprot - A0A0R4J0B1
swissprot - Q3T9A3
swissprot - E9QMP6
swissprot - E9Q9N6
swissprot - E9Q8H5
Ensembl - ENSMUSG00000024969
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mark2aENSDARG00000079905Danio rerio
 mark2bENSDARG00000032458Danio rerio
 MARK2ENSG00000072518Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mark1 / Q8VHJ5 / Serine/threonine-protein kinase MARK1 / Q9P0L2* / microtubule affinity regulating kinase 1*ENSMUSG0000002662068
Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*ENSMUSG0000000741163
Mark4 / Q8CIP4 / MAP/microtubule affinity-regulating kinase 4 / Q96L34* / microtubule affinity regulating kinase 4*ENSMUSG0000003039753
Sik3 / SIK family kinase 3ENSMUSG0000003413533
Sik2 / salt inducible kinase 2 / Q9H0K1*ENSMUSG0000003711229
Sik1 / Q60670 / Serine/threonine-protein kinase SIK1 / SIK1B* / P57059* / salt inducible kinase 1* / salt inducible kinase 1B (putative)*ENSMUSG0000002404228
Snrk / Q8VDU5 / Mus musculus SNF related kinase (Snrk), transcript variant 5, mRNA. / Q9NRH2* / SNF related kinase*ENSMUSG0000003814526
Nim1k / Q8BHI9 / Serine/threonine-protein kinase NIM1 / Q8IY84* / NIM1 serine/threonine protein kinase*ENSMUSG0000009593020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IEA
 biological_processGO:0050770 regulation of axonogenesis IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0097427 microtubule bundle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000315 hemoglobinuria "the presence of hemoglobin in the urine, including certain closely related pigments that are formed from slight alteration of the hemoglobin molecule" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mark2tm1Hpw/Mark2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Mark2tm1Hpw/Mark2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Mark2tm1Hpw/Mark2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Mark2Gt(pSABetageo)38Bss/Mark2+
Genetic Background: involves: 129S2/SvPas * MF1

Allelic Composition: Mark2tm1Hpw/Mark2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mark2tm1Hpw/Mark2+,Mark3tm1Hpw/Mark3tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw,Mark3tm1Hpw/Mark3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Mark2tm1Hpw/Mark2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Mark2Gt(pSABetageo)38Bss/Mark2+
Genetic Background: involves: 129S2/SvPas * MF1

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mark2tm1Hpw/Mark2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mark2tm1Hpw/Mark2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw,Mark3tm1Hpw/Mark3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Mark2tm1Hpw/Mark2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005139 increased prolactin level "greater than expected concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005361 small pituitary gland "reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pthlhtm1Hmk/Pthlhtm1Hmk
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011567 increased renal glomerulus lobularity "distortion of the renal glomerular architecture usually accompanied by increased mesangial cell proliferation and following crowding of the proliferated cells towards the axis of the capillary loops and peripheral recanalization, giving the glomerular tuft a lobular or hypersegmented appearance" [MGI:anna]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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