ENSMUSG00000030397


Mus musculus

Features
Gene ID: ENSMUSG00000030397
  
Biological name :Mark4
  
Synonyms : MAP/microtubule affinity-regulating kinase 4 / Mark4 / Q8CIP4
  
Possible biological names infered from orthology : microtubule affinity regulating kinase 4 / Q96L34
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19424775
Gene end: 19458821
  
Corresponding Affymetrix probe sets: 10560510 (MoGene1.0st)   1439051_a_at (Mouse Genome 430 2.0 Array)   1453569_s_at (Mouse Genome 430 2.0 Array)   1456618_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082862
Ensembl peptide - ENSMUSP00000147002
NCBI entrez gene - 232944     See in Manteia.
MGI - MGI:1920955
RefSeq - XM_011250513
RefSeq - NM_172279
RefSeq - XM_006539829
RefSeq Peptide - NP_758483
swissprot - Q8CIP4
swissprot - A0A140LIY2
Ensembl - ENSMUSG00000030397
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MARK4ENSDARG00000024966Danio rerio
 mark4aENSDARG00000023914Danio rerio
 MARK4ENSG00000007047Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*ENSMUSG0000000741163
Mark1 / Q8VHJ5 / Serine/threonine-protein kinase MARK1 / Q9P0L2* / microtubule affinity regulating kinase 1*ENSMUSG0000002662059
Mark2 / microtubule affinity regulating kinase 2 / Q7KZI7*ENSMUSG0000002496955
Sik3 / SIK family kinase 3ENSMUSG0000003413533
Sik2 / salt inducible kinase 2 / Q9H0K1*ENSMUSG0000003711231
Sik1 / Q60670 / Serine/threonine-protein kinase SIK1 / SIK1B* / P57059* / salt inducible kinase 1* / salt inducible kinase 1B (putative)*ENSMUSG0000002404230
Snrk / Q8VDU5 / Mus musculus SNF related kinase (Snrk), transcript variant 5, mRNA. / Q9NRH2* / SNF related kinase*ENSMUSG0000003814527
Nim1k / Q8BHI9 / Serine/threonine-protein kinase NIM1 / Q8IY84* / NIM1 serine/threonine protein kinase*ENSMUSG0000009593021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization ISO
 biological_processGO:0001578 microtubule bundle formation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000930 gamma-tubulin complex ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043015 gamma-tubulin binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity IEA


Pathways (from Reactome)
Pathway description
Anchoring of the basal body to the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

Allelic Composition: Mark4Gt(XG191)Byg/Mark4Gt(XG191)Byg
Genetic Background: B6.129P2-Mark4Gt(XG191)Byg

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

Allelic Composition: Mark4Gt(XG191)Byg/Mark4Gt(XG191)Byg
Genetic Background: B6.129P2-Mark4Gt(XG191)Byg

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

Allelic Composition: Mark4Gt(XG191)Byg/Mark4Gt(XG191)Byg
Genetic Background: B6.129P2-Mark4Gt(XG191)Byg

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

Allelic Composition: Mark4Gt(XG191)Byg/Mark4Gt(XG191)Byg
Genetic Background: B6.129P2-Mark4Gt(XG191)Byg

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

Allelic Composition: Mark4Gt(XG191)Byg/Mark4Gt(XG191)Byg
Genetic Background: B6.129P2-Mark4Gt(XG191)Byg

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Tlr4tm1.1Djh/Tlr4tm1.1Djh
Genetic Background: involves: FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000090100 Ttbk2 / Q3UVR3 / tau tubulin kinase 2 / Q6IQ55*  / complex / reaction






 

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