ENSMUSG00000090100


Mus musculus

Features
Gene ID: ENSMUSG00000090100
  
Biological name :Ttbk2
  
Synonyms : Q3UVR3 / tau tubulin kinase 2 / Ttbk2
  
Possible biological names infered from orthology : Q6IQ55
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 120732816
Gene end: 120850604
  
Corresponding Affymetrix probe sets: 10486595 (MoGene1.0st)   1421485_at (Mouse Genome 430 2.0 Array)   1428371_at (Mouse Genome 430 2.0 Array)   1436647_at (Mouse Genome 430 2.0 Array)   1440734_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055032
Ensembl peptide - ENSMUSP00000121996
Ensembl peptide - ENSMUSP00000118905
Ensembl peptide - ENSMUSP00000083001
Ensembl peptide - ENSMUSP00000028740
NCBI entrez gene - 140810     See in Manteia.
MGI - MGI:2155779
RefSeq - NM_001024856
RefSeq - NM_001024857
RefSeq - NM_080788
RefSeq Peptide - NP_001020028
RefSeq Peptide - NP_542966
RefSeq Peptide - NP_001020027
swissprot - Q3UVR3
swissprot - A2AW14
swissprot - A2AW13
swissprot - A2AW15
Ensembl - ENSMUSG00000090100
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttbk2aENSDARG00000005670Danio rerio
 ttbk2bENSDARG00000043026Danio rerio
 TTBK2ENSGALG00000009176Gallus gallus
 TTBK2ENSG00000128881Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ttbk1 / Q6PCN3 / tau tubulin kinase 1 / Q5TCY1*ENSMUSG0000001559938
Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*ENSMUSG0000002516210
Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*ENSMUSG000000224339
Q8BK63 / Csnk1a1 / casein kinase 1, alpha 1 / P48729*ENSMUSG000000245768


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization ISO
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007026 negative regulation of microtubule depolymerization ISO
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0008589 regulation of smoothened signaling pathway IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISS
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021681 cerebellar granular layer development IMP
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0021935 cerebellar granule cell precursor tangential migration IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030334 regulation of cell migration ISO
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0060271 cilium assembly ISO
 biological_processGO:1902817 negative regulation of protein localization to microtubule ISO
 biological_processGO:1902857 positive regulation of non-motile cilium assembly IMP
 biological_processGO:1903828 negative regulation of cellular protein localization IMP
 biological_processGO:1904527 negative regulation of microtubule binding ISO
 biological_processGO:1990403 embryonic brain development IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0035869 ciliary transition zone ISO
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019894 kinesin binding ISO


Pathways (from Reactome)
Pathway description
Anchoring of the basal body to the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Phf2tm1.2Yima/Phf2tm1.2Yima,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Phf2tm1.2Yima/Phf2tm1.2Yima,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Phf2tm1.2Yima/Phf2tm1.2Yima,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Phf2tm1.2Yima/Phf2tm1.2Yima,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Phf2tm1.2Yima/Phf2tm1.2Yima,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Phf2tm1.2Yima/Phf2tm1.2Yima,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Phf2tm1.2Yima/Phf2tm1.2Yima,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Hax1tm1.1Gach/Hax1tm1.1Gach
Genetic Background: involves: BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030397 Mark4 / Q8CIP4 / MAP/microtubule affinity-regulating kinase 4 / Q96L34* / microtubule affinity regulating kinase 4*  / complex / reaction






 

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