ENSMUSG00000024576


Mus musculus

Features
Gene ID: ENSMUSG00000024576
  
Biological name :Csnk1a1
  
Synonyms : casein kinase 1, alpha 1 / Csnk1a1 / Q8BK63
  
Possible biological names infered from orthology : P48729
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 61555274
Gene end: 61590061
  
Corresponding Affymetrix probe sets: 10456120 (MoGene1.0st)   1424827_a_at (Mouse Genome 430 2.0 Array)   1428537_at (Mouse Genome 430 2.0 Array)   1430529_at (Mouse Genome 430 2.0 Array)   1437923_at (Mouse Genome 430 2.0 Array)   1451497_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127463
Ensembl peptide - ENSMUSP00000128871
Ensembl peptide - ENSMUSP00000132083
Ensembl peptide - ENSMUSP00000131687
Ensembl peptide - ENSMUSP00000129295
Ensembl peptide - ENSMUSP00000110901
Ensembl peptide - ENSMUSP00000127144
Ensembl peptide - ENSMUSP00000127265
NCBI entrez gene - 93687     See in Manteia.
MGI - MGI:1934950
RefSeq - XM_006526388
RefSeq - XM_006526387
RefSeq - XM_006526384
RefSeq - XM_006526383
RefSeq - XM_006526386
RefSeq - XM_006526385
RefSeq - NM_146087
RefSeq - XM_011247048
RefSeq Peptide - NP_666199
RefSeq Peptide - NP_001344427
RefSeq Peptide - NP_001344428
RefSeq Peptide - NP_001344429
swissprot - Q8BK63
swissprot - Q6PJ87
swissprot - E9Q4G7
swissprot - E9PWB2
swissprot - H7BXB1
swissprot - F6YBC9
swissprot - E9Q2U6
swissprot - E9Q3W1
Ensembl - ENSMUSG00000024576
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csnk1a1ENSDARG00000052674Danio rerio
 P67962ENSGALG00000001364Gallus gallus
 P48729ENSG00000113712Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*ENSMUSG0000002243370
Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*ENSMUSG0000002516270
Ttbk1 / Q6PCN3 / tau tubulin kinase 1 / Q5TCY1*ENSMUSG0000001559934
Ttbk2 / Q3UVR3 / tau tubulin kinase 2 / Q6IQ55*ENSMUSG0000009010034


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006909 phagocytosis IBA
 biological_processGO:0007030 Golgi organization ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0016055 Wnt signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0045104 intermediate filament cytoskeleton organization ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:1904424 regulation of GTP binding ISO
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005847 mRNA cleavage and polyadenylation specificity factor complex ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium TAS
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0030877 beta-catenin destruction complex ISS
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045095 keratin filament ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
GLI3 is processed to GLI3R by the proteasome
Activation of SMO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Fgfrl1tm2.1True/Fgfrl1+
Genetic Background: B6.Cg-Fgfrl1tm2.1True

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn,Tg(Vil-cre/ERT2)23Syr/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * C57BL/6 * CD-1 * DBA/2

Allelic Composition: Csnk1a1tm1.1Ybn/Csnk1a1+,Tg(Vil-cre/ERT2)23Syr/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * C57BL/6 * CD-1 * DBA/2

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn,Tg(Vil-cre/ERT2)23Syr/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * C57BL/6 * CD-1 * DBA/2

Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0004120 cardiac ischemia "inadequate blood blow to the heart; may cause infarction and is usually caused by coronary artery disease" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn,Tg(Vil-cre/ERT2)23Syr/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * C57BL/6 * CD-1 * DBA/2

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn,Tg(Vil-cre/ERT2)23Syr/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * C57BL/6 * CD-1 * DBA/2

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * DBA/2

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Csnk1a1tm1.1Ybn/Csnk1a1+,Tg(Vil-cre/ERT2)23Syr/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129 * C57BL/6 * CD-1 * DBA/2

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0013657 abnormal blood cell morphology "any structural anomaly of cells found in the blood" [CL:0000081]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0013659 abnormal erythroid lineage cell morphology "any structural anomaly of an immature or mature cell in the lineage leading to and including erythrocytes" [CL:0000764]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0013662 decreased myeloid cell number "reduction in the expected number of cells of the myeloid lineage" [CL:0000763]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

 MP:0013776 bone marrow failure "inherited or acquired dysfunction of hematopoietic stem cells that can result in abnormalities in one or more of the stem cell lineages (erythroid, myeloid, megakaryocytic)" [http://emedicine.medscape.com/article/199003-overview, MGI:llw2]
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Allelic Composition: Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001761 Smo / P56726 / smoothened, frizzled class receptor / Q99835*  / complex / reaction
 ENSMUSG00000024858 Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*  / reaction / complex
 ENSMUSG00000021318 Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*  / reaction
 ENSMUSG00000025231 Sufu / Q9Z0P7 / SUFU negative regulator of hedgehog signaling / Q9UMX1*  / reaction






 

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