ENSG00000113712


Homo sapiens

Features
Gene ID: ENSG00000113712
  
Biological name :CSNK1A1
  
Synonyms : casein kinase 1 alpha 1 / CSNK1A1 / P48729
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q32
Gene start: 149492197
Gene end: 149551552
  
Corresponding Affymetrix probe sets: 205764_at (Human Genome U133 Plus 2.0 Array)   206562_s_at (Human Genome U133 Plus 2.0 Array)   208865_at (Human Genome U133 Plus 2.0 Array)   208866_at (Human Genome U133 Plus 2.0 Array)   208867_s_at (Human Genome U133 Plus 2.0 Array)   213086_s_at (Human Genome U133 Plus 2.0 Array)   213860_x_at (Human Genome U133 Plus 2.0 Array)   226920_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426747
Ensembl peptide - ENSP00000475969
Ensembl peptide - ENSP00000475633
Ensembl peptide - ENSP00000475319
Ensembl peptide - ENSP00000430252
Ensembl peptide - ENSP00000427031
Ensembl peptide - ENSP00000261798
Ensembl peptide - ENSP00000367074
Ensembl peptide - ENSP00000421268
Ensembl peptide - ENSP00000421689
Ensembl peptide - ENSP00000425366
NCBI entrez gene - 1452     See in Manteia.
OMIM - 600505
RefSeq - NM_001892
RefSeq - NM_001025105
RefSeq - NM_001271741
RefSeq - NM_001271742
RefSeq Peptide - NP_001020276
RefSeq Peptide - NP_001258670
RefSeq Peptide - NP_001258671
RefSeq Peptide - NP_001883
swissprot - U3KQK7
swissprot - E5RG27
swissprot - D6RGE5
swissprot - D6REM4
swissprot - H0Y9X2
swissprot - P48729
swissprot - U3KPX3
swissprot - U3KQ83
swissprot - E7ETM0
Ensembl - ENSG00000113712
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csnk1a1ENSDARG00000052674Danio rerio
 P67962ENSGALG00000001364Gallus gallus
 Q8BK63ENSMUSG00000024576Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8N752 / CSNK1A1L / casein kinase 1 alpha 1 likeENSG0000018013884
Z98749.3ENSG0000028390064
CSNK1E / P49674 / casein kinase 1 epsilonENSG0000021392364
CSNK1D / P48730 / casein kinase 1 deltaENSG0000014155163
TTBK1 / Q5TCY1 / tau tubulin kinase 1ENSG0000014621631
TTBK2 / Q6IQ55 / tau tubulin kinase 2ENSG0000012888130


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006909 phagocytosis IBA
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0016055 Wnt signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IMP
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0045104 intermediate filament cytoskeleton organization IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IC
 biological_processGO:1904424 regulation of GTP binding IMP
 biological_processGO:1904885 beta-catenin destruction complex assembly TAS
 biological_processGO:1904886 beta-catenin destruction complex disassembly TAS
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030877 beta-catenin destruction complex IDA
 cellular_componentGO:0036064 ciliary basal body ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045095 keratin filament IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Misspliced GSK3beta mutants stabilize beta-catenin
S33 mutants of beta-catenin arent phosphorylated
S37 mutants of beta-catenin arent phosphorylated
S45 mutants of beta-catenin arent phosphorylated
T41 mutants of beta-catenin arent phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Activation of SMO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000128602 SMO / Q99835 / smoothened, frizzled class receptor  / complex / reaction
 ENSG00000074047 GLI2 / P10070 / GLI family zinc finger 2  / reaction
 ENSG00000173020 GRK2 / P25098 / G protein-coupled receptor kinase 2  / complex / reaction
 ENSG00000107882 SUFU / Q9UMX1 / SUFU negative regulator of hedgehog signaling  / reaction
 ENSG00000106571 GLI3 / P10071 / GLI family zinc finger 3  / reaction






 

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