ENSMUSG00000025162


Mus musculus

Features
Gene ID: ENSMUSG00000025162
  
Biological name :Csnk1d
  
Synonyms : casein kinase 1, delta / Csnk1d / Q9DC28
  
Possible biological names infered from orthology : P48730
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120961749
Gene end: 120991330
  
Corresponding Affymetrix probe sets: 10394040 (MoGene1.0st)   1415825_s_at (Mouse Genome 430 2.0 Array)   1418889_a_at (Mouse Genome 430 2.0 Array)   1437690_x_at (Mouse Genome 430 2.0 Array)   1449932_at (Mouse Genome 430 2.0 Array)   1456727_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018274
Ensembl peptide - ENSMUSP00000070721
Ensembl peptide - ENSMUSP00000115055
Ensembl peptide - ENSMUSP00000117472
NCBI entrez gene - 104318     See in Manteia.
MGI - MGI:1355272
RefSeq - XM_011248663
RefSeq - NM_027874
RefSeq - NM_139059
RefSeq - XM_011248662
RefSeq Peptide - NP_082150
RefSeq Peptide - NP_620690
swissprot - Q3UBT6
swissprot - F7A4U8
swissprot - Q9DC28
swissprot - F6VU53
Ensembl - ENSMUSG00000025162
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6P3K7ENSDARG00000006125Danio rerio
 Q7T2E3ENSDARG00000008370Danio rerio
 CSNK1DENSGALG00000002719Gallus gallus
 CSNK1DENSG00000141551Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*ENSMUSG0000002243384
Q8BK63 / Csnk1a1 / casein kinase 1, alpha 1 / P48729*ENSMUSG0000002457655
Ttbk1 / Q6PCN3 / tau tubulin kinase 1 / Q5TCY1*ENSMUSG0000001559932
Ttbk2 / Q3UVR3 / tau tubulin kinase 2 / Q6IQ55*ENSMUSG0000009010031


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006897 endocytosis IBA
 biological_processGO:0007020 microtubule nucleation IEA
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IGI
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0034067 protein localization to Golgi apparatus IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051225 spindle assembly IEA
 biological_processGO:0061512 protein localization to cilium IEA
 biological_processGO:0071539 protein localization to centrosome IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1905426 positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation IC
 biological_processGO:1905515 non-motile cilium assembly IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:2000052 positive regulation of non-canonical Wnt signaling pathway IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Csnk1dtm1.1Drw/Csnk1dtm1.1Drw
Genetic Background: B6.129S4-Csnk1dtm1.1Drw

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Csnk1dtm1.1Drw/Csnk1dtm1.1Drw
Genetic Background: B6.129S4-Csnk1dtm1.1Drw

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Csnk1dtm1.1Drw/Csnk1dtm1.1Drw
Genetic Background: B6.129S4-Csnk1dtm1.1Drw

 MP:0020469 prolonged circadian behavior period "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Csnk1dtm1.1Drw/Csnk1dtm1.1Drw
Genetic Background: B6.129S4-Csnk1dtm1.1Drw

Allelic Composition: Csnk1dGt(TEA020)Byg/Csnk1d+,Tg(PER2*S662D)382Ljp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Per2tm1Drw/Per2tm1Drw,Tg(PER2*S662G)867Ljp/0
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000068742 Cry2 / Q9R194 / Cryptochrome-2 / Q49AN0* / cryptochrome circadian regulator 2*  / reaction / complex
 ENSMUSG00000022433 Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*  / reaction
 ENSMUSG00000029238 Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*  / complex / reaction
 ENSMUSG00000002546 Golga2 / Q921M4 / golgi autoantigen, golgin subfamily a, 2 / A7E2F4* / A8MQT2* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / A6NMD2* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* ...  / reaction
 ENSMUSG00000001052 Sec24b / Sec24 related gene family, member B (S. cerevisiae) / O95487* / SEC24 homolog B, COPII coat complex component*  / reaction
 ENSMUSG00000030298 Sec13 / Q9D1M0 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735*  / reaction
 ENSMUSG00000020986 Q01405 / Sec23a / Protein transport protein Sec23A / Q15436* / Sec23 homolog A, coat complex II component*  / reaction
 ENSMUSG00000025162 Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*  / reaction
 ENSMUSG00000029407 Uso1 / Q9Z1Z0 / USO1 vesicle docking factor / O60763* / USO1 vesicle transport factor*  / reaction
 ENSMUSG00000020038 Cry1 / P97784 / Cryptochrome-1 / Q16526* / cryptochrome circadian regulator 1*  / complex / reaction
 ENSMUSG00000020893 Per1 / O35973 / Period circadian protein homolog 1 / O15534* / period circadian regulator 1*  / complex / reaction
 ENSMUSG00000020149 Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*  / reaction
 ENSMUSG00000055116 Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*  / reaction / complex
 ENSMUSG00000039234 Sec24d / Sec24 related gene family, member D (S. cerevisiae) / O94855* / SEC24 homolog D, COPII coat complex component*  / reaction
 ENSMUSG00000055319 Sec23ip / Sec23 interacting protein / Q9Y6Y8*  / reaction
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / reaction
 ENSMUSG00000032513 Q91X51 / Gorasp1 / golgi reassembly stacking protein 1 / Q9BQQ3*  / reaction
 ENSMUSG00000036391 Q3U2P1 / Sec24a / Protein transport protein Sec24A / O95486* / SEC24 homolog A, COPII coat complex component*  / reaction
 ENSMUSG00000035325 Q3UPL0 / Sec31a / Protein transport protein Sec31A / O94979* / SEC31 homolog A, COPII coat complex component*  / reaction






 

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