ENSMUSG00000020038


Mus musculus

Features
Gene ID: ENSMUSG00000020038
  
Biological name :Cry1
  
Synonyms : Cry1 / Cryptochrome-1 / P97784
  
Possible biological names infered from orthology : cryptochrome circadian regulator 1 / Q16526
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 85131700
Gene end: 85185064
  
Corresponding Affymetrix probe sets: 10371400 (MoGene1.0st)   1433733_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020227
Ensembl peptide - ENSMUSP00000150910
NCBI entrez gene - 12952     See in Manteia.
MGI - MGI:1270841
RefSeq - XM_011243349
RefSeq - NM_007771
RefSeq - XM_011243348
RefSeq Peptide - NP_031797
swissprot - P97784
swissprot - A0A1L1SUT8
Ensembl - ENSMUSG00000020038
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cry1aaENSDARG00000045768Danio rerio
 cry1abENSDARG00000011583Danio rerio
 CRY1ENSGALG00000012638Gallus gallus
 CRY1ENSG00000008405Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cry2 / Q9R194 / Cryptochrome-2 / Q49AN0* / cryptochrome circadian regulator 2*ENSMUSG0000006874268


Protein motifs (from Interpro)
Interpro ID Name
 IPR005101  Cryptochrome/DNA photolyase, FAD-binding domain
 IPR006050  DNA photolyase, N-terminal
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR036134  Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily
 IPR036155  Cryptochrome/photolyase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006094 gluconeogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006975 DNA damage induced protein phosphorylation IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0018298 protein-chromophore linkage IEA
 biological_processGO:0019915 lipid storage IGI
 biological_processGO:0031397 negative regulation of protein ubiquitination IDA
 biological_processGO:0032868 response to insulin IGI
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0033762 response to glucagon IMP
 biological_processGO:0042593 glucose homeostasis IGI
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0042754 negative regulation of circadian rhythm IMP
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:2000001 regulation of DNA damage checkpoint IDA
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway IGI
 biological_processGO:2000850 negative regulation of glucocorticoid secretion IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0009881 photoreceptor activity IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000250 abnormal vasoconstriction "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl2l11tm6.1Boui/Bcl2l11tm6.1Boui,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0004184 abnormal baroreceptor physiology "anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006243 abnormal pupil dilation reaction to light "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0008454 absent retinal rod cells "absence of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011021 abnormal circadian regulation of heart rate "anomaly in the process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours" [GO:0003053]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011022 abnormal circadian regulation of systemic arterial blood pressure "any anomaly in the process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours" [GO:0003052]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020468 abnormal circadian behavior period "any change in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Genetic Background: involves: 129P2/OlaHsd

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020472 arrhythmic circadian behavior persistence "loss of a behavioral rhythmic pattern upon removal of time cues" [MGI:smb]
Show

Allelic Composition: Mettm1Cpo/Mettm2Cpo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Per2tm1Brd/Per2tm1Brd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

 MP:0020477 abnormal locomotor circadian rhythm "any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475]
Show

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025162 Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*  / reaction / complex
 ENSMUSG00000029238 Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*  / reaction / complex
 ENSMUSG00000022433 Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*  / complex / reaction
 ENSMUSG00000055116 Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*  / reaction / complex
 ENSMUSG00000020893 Per1 / O35973 / Period circadian protein homolog 1 / O15534* / period circadian regulator 1*  / complex
 ENSMUSG00000022124 Fbxl3 / Q8C4V4 / F-box/LRR-repeat protein 3 / Q9UKT7* / F-box and leucine rich repeat protein 3*  / reaction / complex






 

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