ENSG00000008405


Homo sapiens

Features
Gene ID: ENSG00000008405
  
Biological name :CRY1
  
Synonyms : CRY1 / cryptochrome circadian regulator 1 / Q16526
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q23.3
Gene start: 106991364
Gene end: 107093829
  
Corresponding Affymetrix probe sets: 209674_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000447738
Ensembl peptide - ENSP00000008527
NCBI entrez gene - 1407     See in Manteia.
OMIM - 601933
RefSeq - XM_017018832
RefSeq - NM_004075
RefSeq Peptide - NP_004066
swissprot - A2I2P0
swissprot - Q16526
swissprot - H0YHT0
Ensembl - ENSG00000008405
  
Related genetic diseases (OMIM): 614163 - {Delayed sleep phase disorder, susceptibility to}, 614163
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cry1aaENSDARG00000045768Danio rerio
 cry1abENSDARG00000011583Danio rerio
 CRY1ENSGALG00000012638Gallus gallus
 Cry1ENSMUSG00000020038Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CRY2 / Q49AN0 / cryptochrome circadian regulator 2ENSG0000012167170


Protein motifs (from Interpro)
Interpro ID Name
 IPR005101  Cryptochrome/DNA photolyase, FAD-binding domain
 IPR006050  DNA photolyase, N-terminal
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR036134  Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily
 IPR036155  Cryptochrome/photolyase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006094 gluconeogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006975 DNA damage induced protein phosphorylation ISS
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009785 blue light signaling pathway NAS
 biological_processGO:0018298 protein-chromophore linkage IEA
 biological_processGO:0019915 lipid storage IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination ISS
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0033762 response to glucagon ISS
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0042754 negative regulation of circadian rhythm ISS
 biological_processGO:0043153 entrainment of circadian clock by photoperiod ISS
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:2000001 regulation of DNA damage checkpoint ISS
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway ISS
 biological_processGO:2000850 negative regulation of glucocorticoid secretion IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003690 double-stranded DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0009881 photoreceptor activity IEA
 molecular_functionGO:0009882 blue light photoreceptor activity NAS
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019902 phosphatase binding IPI
 molecular_functionGO:0035257 nuclear hormone receptor binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IEA


Pathways (from Reactome)
Pathway description
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000179094 PER1 / O15534 / period circadian regulator 1  / complex
 ENSG00000133794 ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator like  / complex / reaction
 ENSG00000170485 NPAS2 / Q99743 / neuronal PAS domain protein 2  / complex / reaction
 ENSG00000005812 FBXL3 / Q9UKT7 / F-box and leucine rich repeat protein 3  / complex / reaction
 ENSG00000134852 CLOCK / O15516 / clock circadian regulator  / reaction / complex
 ENSG00000132326 PER2 / O15055 / period circadian regulator 2  / complex
 ENSG00000213923 CSNK1E / P49674 / casein kinase 1 epsilon  / complex






 

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