ENSG00000121671


Homo sapiens

Features
Gene ID: ENSG00000121671
  
Biological name :CRY2
  
Synonyms : CRY2 / cryptochrome circadian regulator 2 / Q49AN0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p11.2
Gene start: 45847118
Gene end: 45883248
  
Corresponding Affymetrix probe sets: 212695_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397419
Ensembl peptide - ENSP00000484684
Ensembl peptide - ENSP00000478187
Ensembl peptide - ENSP00000406751
NCBI entrez gene - 1408     See in Manteia.
OMIM - 603732
RefSeq - NM_001127457
RefSeq - NM_021117
RefSeq Peptide - NP_001120929
RefSeq Peptide - NP_066940
swissprot - Q49AN0
swissprot - A0A0D2X7Z3
swissprot - A2I2P1
Ensembl - ENSG00000121671
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cry2ENSDARG00000102403Danio rerio
 CRY2ENSGALG00000008436Gallus gallus
 Cry2ENSMUSG00000068742Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CRY1 / Q16526 / cryptochrome circadian regulator 1ENSG0000000840567


Protein motifs (from Interpro)
Interpro ID Name
 IPR005101  Cryptochrome/DNA photolyase, FAD-binding domain
 IPR006050  DNA photolyase, N-terminal
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR036134  Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily
 IPR036155  Cryptochrome/photolyase, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009416 response to light stimulus IMP
 biological_processGO:0009785 blue light signaling pathway NAS
 biological_processGO:0018298 protein-chromophore linkage IEA
 biological_processGO:0019915 lipid storage IEA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IDA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0042754 negative regulation of circadian rhythm IEA
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:2000118 regulation of sodium-dependent phosphate transport IDA
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway IEA
 biological_processGO:2000850 negative regulation of glucocorticoid secretion IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009881 photoreceptor activity IEA
 molecular_functionGO:0009882 blue light photoreceptor activity NAS
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019902 phosphatase binding IPI
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0071949 FAD binding IEA


Pathways (from Reactome)
Pathway description
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132326 PER2 / O15055 / period circadian regulator 2  / complex
 ENSG00000134852 CLOCK / O15516 / clock circadian regulator  / reaction / complex
 ENSG00000179094 PER1 / O15534 / period circadian regulator 1  / complex
 ENSG00000170485 NPAS2 / Q99743 / neuronal PAS domain protein 2  / reaction / complex
 ENSG00000213923 CSNK1E / P49674 / casein kinase 1 epsilon  / complex
 ENSG00000133794 ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator like  / complex / reaction
 ENSG00000005812 FBXL3 / Q9UKT7 / F-box and leucine rich repeat protein 3  / reaction / complex






 

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