ENSG00000179094


Homo sapiens

Features
Gene ID: ENSG00000179094
  
Biological name :PER1
  
Synonyms : O15534 / PER1 / period circadian regulator 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.1
Gene start: 8140472
Gene end: 8156506
  
Corresponding Affymetrix probe sets: 202861_at (Human Genome U133 Plus 2.0 Array)   242832_at (Human Genome U133 Plus 2.0 Array)   244677_at (Human Genome U133 Plus 2.0 Array)   36829_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464696
Ensembl peptide - ENSP00000463385
Ensembl peptide - ENSP00000463661
Ensembl peptide - ENSP00000314420
Ensembl peptide - ENSP00000346979
Ensembl peptide - ENSP00000462064
Ensembl peptide - ENSP00000462546
Ensembl peptide - ENSP00000463054
Ensembl peptide - ENSP00000463369
NCBI entrez gene - 5187     See in Manteia.
OMIM - 602260
RefSeq - XM_005256690
RefSeq - NM_002616
RefSeq - XM_005256689
RefSeq Peptide - NP_002607
swissprot - J3QL55
swissprot - J3QLQ5
swissprot - J3QSH9
swissprot - J3KRL7
swissprot - O15534
swissprot - J3KSL6
swissprot - J3QL46
swissprot - J3KTM2
Ensembl - ENSG00000179094
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 per1aENSDARG00000056885Danio rerio
 per1bENSDARG00000012499Danio rerio
 Per1ENSMUSG00000020893Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PER2 / O15055 / period circadian regulator 2ENSG0000013232642
PER3 / P56645 / period circadian regulator 3ENSG0000004924631


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR013655  PAS fold-3
 IPR022728  Period circadian-like, C-terminal
 IPR035965  PAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0002028 regulation of sodium ion transport ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0009649 entrainment of circadian clock TAS
 biological_processGO:0010608 posttranscriptional regulation of gene expression ISS
 biological_processGO:0032922 circadian regulation of gene expression IDA
 biological_processGO:0042634 regulation of hair cycle IMP
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043153 entrainment of circadian clock by photoperiod ISS
 biological_processGO:0043966 histone H3 acetylation IDA
 biological_processGO:0043967 histone H4 acetylation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046329 negative regulation of JNK cascade ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0070932 histone H3 deacetylation ISS
 biological_processGO:0097167 circadian regulation of translation ISS
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response ISS
 biological_processGO:1900744 regulation of p38MAPK cascade ISS
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0031490 chromatin DNA binding ISS
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000008405 CRY1 / Q16526 / cryptochrome circadian regulator 1  / complex
 ENSG00000132326 PER2 / O15055 / period circadian regulator 2  / complex
 ENSG00000170485 NPAS2 / Q99743 / neuronal PAS domain protein 2  / reaction / complex
 ENSG00000134852 CLOCK / O15516 / clock circadian regulator  / complex / reaction
 ENSG00000121671 CRY2 / Q49AN0 / cryptochrome circadian regulator 2  / complex
 ENSG00000179094 PER1 / O15534 / period circadian regulator 1  / complex
 ENSG00000133794 ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator like  / reaction / complex
 ENSG00000213923 CSNK1E / P49674 / casein kinase 1 epsilon  / complex
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / reaction / complex






 

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