ENSG00000170485


Homo sapiens

Features
Gene ID: ENSG00000170485
  
Biological name :NPAS2
  
Synonyms : neuronal PAS domain protein 2 / NPAS2 / Q99743
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q11.2
Gene start: 100820152
Gene end: 100996829
  
Corresponding Affymetrix probe sets: 205459_s_at (Human Genome U133 Plus 2.0 Array)   205460_at (Human Genome U133 Plus 2.0 Array)   213462_at (Human Genome U133 Plus 2.0 Array)   39548_at (Human Genome U133 Plus 2.0 Array)   39549_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395265
Ensembl peptide - ENSP00000393396
Ensembl peptide - ENSP00000397595
Ensembl peptide - ENSP00000338283
Ensembl peptide - ENSP00000388528
Ensembl peptide - ENSP00000392125
NCBI entrez gene - 4862     See in Manteia.
OMIM - 603347
RefSeq - XM_017004217
RefSeq - XM_005263959
RefSeq - XM_005263960
RefSeq - XM_005263961
RefSeq - XM_011511242
RefSeq - XM_011511243
RefSeq - XM_017004214
RefSeq - XM_017004215
RefSeq - XM_017004216
RefSeq - NM_002518
RefSeq - XM_005263953
RefSeq Peptide - NP_002509
swissprot - H7BZY5
swissprot - H7C080
swissprot - H7C0J4
swissprot - H7C0Z2
swissprot - A2I2P5
swissprot - H7BZA3
swissprot - Q99743
Ensembl - ENSG00000170485
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npas2ENSDARG00000016536Danio rerio
 NPAS2ENSGALG00000016774Gallus gallus
 Npas2ENSMUSG00000026077Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLOCK / O15516 / clock circadian regulatorENSG0000013485250
ARNT / P27540 / aryl hydrocarbon receptor nuclear translocatorENSG0000014343719
ARNT2 / Q9HBZ2 / aryl hydrocarbon receptor nuclear translocator 2ENSG0000017237918
ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator likeENSG0000013379416
ARNTL2 / Q8WYA1 / aryl hydrocarbon receptor nuclear translocator like 2ENSG0000002915316
EPAS1 / Q99814 / endothelial PAS domain protein 1ENSG0000011601616
HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunitENSG0000010064415
SIM2 / Q14190 / single-minded family bHLH transcription factor 2ENSG0000015926314
HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunitENSG0000012444013
SIM1 / P81133 / single-minded family bHLH transcription factor 1ENSG0000011224613
NPAS3 / Q8IXF0 / neuronal PAS domain protein 3ENSG0000015132212
NPAS1 / Q99742 / neuronal PAS domain protein 1ENSG000001307519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001067  Nuclear translocator
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0045739 positive regulation of DNA repair IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051775 response to redox state IDA
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:2001020 regulation of response to DNA damage stimulus IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001047 core promoter binding ISS
 molecular_functionGO:0003677 DNA binding IPI
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0051879 Hsp90 protein binding IDA


Pathways (from Reactome)
Pathway description
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000008405 CRY1 / Q16526 / cryptochrome circadian regulator 1  / reaction / complex
 ENSG00000132326 PER2 / O15055 / period circadian regulator 2  / reaction / complex
 ENSG00000179094 PER1 / O15534 / period circadian regulator 1  / complex / reaction
 ENSG00000121671 CRY2 / Q49AN0 / cryptochrome circadian regulator 2  / complex / reaction
 ENSG00000213923 CSNK1E / P49674 / casein kinase 1 epsilon  / reaction / complex
 ENSG00000133794 ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator like  / complex / reaction






 

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