ENSG00000029153


Homo sapiens

Features
Gene ID: ENSG00000029153
  
Biological name :ARNTL2
  
Synonyms : ARNTL2 / aryl hydrocarbon receptor nuclear translocator like 2 / Q8WYA1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p11.23
Gene start: 27332854
Gene end: 27425289
  
Corresponding Affymetrix probe sets: 220658_s_at (Human Genome U133 Plus 2.0 Array)   223586_at (Human Genome U133 Plus 2.0 Array)   224204_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445836
Ensembl peptide - ENSP00000438545
Ensembl peptide - ENSP00000442438
Ensembl peptide - ENSP00000261178
Ensembl peptide - ENSP00000266503
Ensembl peptide - ENSP00000312247
Ensembl peptide - ENSP00000379238
Ensembl peptide - ENSP00000400185
NCBI entrez gene - 56938     See in Manteia.
OMIM - 614517
RefSeq - XM_017019669
RefSeq - NM_001248002
RefSeq - NM_001248003
RefSeq - NM_001248004
RefSeq - NM_001248005
RefSeq - NM_020183
RefSeq - XM_011520768
RefSeq - XM_011520769
RefSeq - XM_011520770
RefSeq - XM_011520771
RefSeq - XM_017019666
RefSeq - XM_017019667
RefSeq - XM_017019668
RefSeq - XM_006719112
RefSeq - XM_006719114
RefSeq - XM_011520766
RefSeq Peptide - NP_001234931
RefSeq Peptide - NP_001234932
RefSeq Peptide - NP_001234933
RefSeq Peptide - NP_001234934
RefSeq Peptide - NP_064568
swissprot - Q8WYA1
swissprot - H0Y5R1
Ensembl - ENSG00000029153
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arntl2ENSDARG00000041381Danio rerio
 ARNTL2ENSGALG00000014096Gallus gallus
 Arntl2ENSMUSG00000040187Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator likeENSG0000013379449
ARNT / P27540 / aryl hydrocarbon receptor nuclear translocatorENSG0000014343731
ARNT2 / Q9HBZ2 / aryl hydrocarbon receptor nuclear translocator 2ENSG0000017237930
CLOCK / O15516 / clock circadian regulatorENSG0000013485221
NPAS2 / Q99743 / neuronal PAS domain protein 2ENSG0000017048520
EPAS1 / Q99814 / endothelial PAS domain protein 1ENSG0000011601618
HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunitENSG0000010064418
NPAS1 / Q99742 / neuronal PAS domain protein 1ENSG0000013075117
NPAS3 / Q8IXF0 / neuronal PAS domain protein 3ENSG0000015132216
SIM2 / Q14190 / single-minded family bHLH transcription factor 2ENSG0000015926316
HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunitENSG0000012444016
SIM1 / P81133 / single-minded family bHLH transcription factor 1ENSG0000011224616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001067  Nuclear translocator
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0007623 circadian rhythm IDA
 biological_processGO:0009649 entrainment of circadian clock NAS
 biological_processGO:0042753 positive regulation of circadian rhythm ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
BMAL1:CLOCK,NPAS2 activates circadian gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134852 CLOCK / O15516 / clock circadian regulator  / complex






 

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