ENSG00000143437


Homo sapiens

Features
Gene ID: ENSG00000143437
  
Biological name :ARNT
  
Synonyms : ARNT / aryl hydrocarbon receptor nuclear translocator / P27540
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 150809705
Gene end: 150876768
  
Corresponding Affymetrix probe sets: 210828_s_at (Human Genome U133 Plus 2.0 Array)   218221_at (Human Genome U133 Plus 2.0 Array)   218222_x_at (Human Genome U133 Plus 2.0 Array)   230619_at (Human Genome U133 Plus 2.0 Array)   231016_s_at (Human Genome U133 Plus 2.0 Array)   233724_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425363
Ensembl peptide - ENSP00000423851
Ensembl peptide - ENSP00000425899
Ensembl peptide - ENSP00000427571
Ensembl peptide - ENSP00000346372
Ensembl peptide - ENSP00000351407
NCBI entrez gene - 405     See in Manteia.
OMIM - 126110
RefSeq - XM_017001296
RefSeq - XM_011509545
RefSeq - XM_011509546
RefSeq - XM_011509547
RefSeq - XM_017001288
RefSeq - XM_017001289
RefSeq - XM_017001290
RefSeq - XM_017001291
RefSeq - XM_017001292
RefSeq - XM_017001293
RefSeq - XM_017001294
RefSeq - XM_017001295
RefSeq - NM_001197325
RefSeq - NM_001286035
RefSeq - NM_001286036
RefSeq - NM_001350224
RefSeq - NM_001350225
RefSeq - NM_001350226
RefSeq - NM_001668
RefSeq - NM_178427
RefSeq - XM_005245151
RefSeq - XM_005245153
RefSeq - XM_005245154
RefSeq - XM_005245157
RefSeq - XM_011509542
RefSeq - XM_011509543
RefSeq - XM_011509544
RefSeq Peptide - NP_001272964
RefSeq Peptide - NP_001272965
RefSeq Peptide - NP_001337153
RefSeq Peptide - NP_001337154
RefSeq Peptide - NP_001337155
RefSeq Peptide - NP_001659
RefSeq Peptide - NP_848514
RefSeq Peptide - NP_001184254
swissprot - A6NGV6
swissprot - D6RDB3
swissprot - P27540
Ensembl - ENSG00000143437
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arntENSDARG00000021855Danio rerio
 ARNTENSGALG00000000751Gallus gallus
 ArntENSMUSG00000015522Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARNT2 / Q9HBZ2 / aryl hydrocarbon receptor nuclear translocator 2ENSG0000017237959
ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator likeENSG0000013379425
ARNTL2 / Q8WYA1 / aryl hydrocarbon receptor nuclear translocator like 2ENSG0000002915325
CLOCK / O15516 / clock circadian regulatorENSG0000013485220
NPAS2 / Q99743 / neuronal PAS domain protein 2ENSG0000017048520
EPAS1 / Q99814 / endothelial PAS domain protein 1ENSG0000011601617
HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunitENSG0000010064416
NPAS3 / Q8IXF0 / neuronal PAS domain protein 3ENSG0000015132215
HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunitENSG0000012444014
SIM1 / P81133 / single-minded family bHLH transcription factor 1ENSG0000011224614
SIM2 / Q14190 / single-minded family bHLH transcription factor 2ENSG0000015926313
NPAS1 / Q99742 / neuronal PAS domain protein 1ENSG0000013075113


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001067  Nuclear translocator
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IC
 biological_processGO:0006351 transcription, DNA-templated TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IC
 biological_processGO:0033235 positive regulation of protein sumoylation IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IC
 biological_processGO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IC
 biological_processGO:0045821 positive regulation of glycolytic process IC
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046886 positive regulation of hormone biosynthetic process IDA
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0004874 aryl hydrocarbon receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding IPI
 molecular_functionGO:0035326 enhancer binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
PPARA activates gene expression
Phase I - Functionalization of compounds
Endogenous sterols
Xenobiotics
Aryl hydrocarbon receptor signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106546 AHR / P35869 / aryl hydrocarbon receptor  / complex / reaction
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex
 ENSG00000116016 EPAS1 / Q99814 / endothelial PAS domain protein 1  / reaction / complex
 ENSG00000063438 AHRR / A9YTQ3 / aryl-hydrocarbon receptor repressor  / reaction / complex
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / complex / reaction
 ENSG00000124440 HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunit  / complex / reaction






 

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