ENSG00000106546


Homo sapiens

Features
Gene ID: ENSG00000106546
  
Biological name :AHR
  
Synonyms : AHR / aryl hydrocarbon receptor / P35869
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p21.1
Gene start: 16916359
Gene end: 17346152
  
Corresponding Affymetrix probe sets: 202820_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000242057
Ensembl peptide - ENSP00000495987
Ensembl peptide - ENSP00000436466
NCBI entrez gene - 196     See in Manteia.
OMIM - 600253
RefSeq - NM_001621
RefSeq Peptide - NP_001612
swissprot - A0A024R9Z8
swissprot - P35869
Ensembl - ENSG00000106546
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ahr1aENSDARG00000020046Danio rerio
 AHRENSGALG00000010836Gallus gallus
 AhrENSMUSG00000019256Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC019117.3ENSG0000028332193
AHRR / A9YTQ3 / aryl-hydrocarbon receptor repressorENSG0000006343823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold
 IPR033348  Aryl hydrocarbon receptor
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009410 response to xenobiotic stimulus IDA
 biological_processGO:0009636 response to toxic substance IDA
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0019933 cAMP-mediated signaling IDA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0030888 regulation of B cell proliferation IDA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:1904322 cellular response to forskolin IDA
 biological_processGO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0034751 aryl hydrocarbon receptor complex IEA
 cellular_componentGO:0034752 cytosolic aryl hydrocarbon receptor complex TAS
 cellular_componentGO:0034753 nuclear aryl hydrocarbon receptor complex IBA
 molecular_functionGO:0001094 TFIID-class transcription factor binding IPI
 molecular_functionGO:0001223 transcription coactivator binding IPI
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0004874 aryl hydrocarbon receptor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0017025 TBP-class protein binding IPI
 molecular_functionGO:0035326 enhancer binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity TAS
 molecular_functionGO:0046983 protein dimerization activity TAS
 molecular_functionGO:0051879 Hsp90 protein binding IDA
 molecular_functionGO:0070888 E-box binding ISS


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Phase I - Functionalization of compounds
Endogenous sterols
Xenobiotics
Aryl hydrocarbon receptor signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / complex
 ENSG00000172379 ARNT2 / Q9HBZ2 / aryl hydrocarbon receptor nuclear translocator 2  / complex / reaction
 ENSG00000143437 ARNT / P27540 / aryl hydrocarbon receptor nuclear translocator  / reaction / complex
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / complex
 ENSG00000110711 AIP / O00170 / aryl hydrocarbon receptor interacting protein  / complex






 

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